Table 2.

Summary of significant clusters for voxel- and surface-based morphometric group effects, group × pain catastrophizing interactions, and migraine disease characteristics

MeasureRegionClusterextentMNI coordinatest/F valueclusterp valueclusterPartial corr CTLPartial corr PAT
xyzrprp
GMV
    PAT > CTLL Hippo.1048−22−15−154.230.011
    PCS: CTL > PATL S11240−42−27544.620.0070.640.008−0.720.002
L mPFC1131−856164.390.0090.230.390−0.710.003
L aMCC893−330164.520.0180.580.018−0.430.110
    Disease durationL pINS2334−34−1622−6.80<0.001
R pINS54544−1224−4.130.029
L IFG519−2747−17−9.050.032
    Attack frequencyL IFG602−385412−6.080.022
L Lingual642−18−63−2−5.080.019
R PCC10253−5230−4.260.004
L PPC665−32−7530−4.740.017
R S1110738−3360−6.400.003
    Pain intensityL aINS918−3614−23−9.200.006
L PCC2919−8−4627−9.90<0.001
L Cerebellum2756−8−42−17−6.69<0.001
R Cerebellum70551−73−32−3.830.014
Cortical thickness
    CTL > PATL aMCC140−329203.53<0.005
    PCS: CTL > PATL DLPFC273−3642243.74<0.0050.560.026−0.700.003
L MTG174−67−24−212.87<0.0050.560.026−0.530.041
R IFG160542024.07<0.0050.530.034−0.740.002
    Disease durationL DLPFC144−204231−3.26<0.005
R DLPFC13845528−3.05<0.005
    Attack frequencyL Lingual101−33−44−8−5.16<0.005
L Lingual116−21−66−9−3.21<0.005
R Lingual36316−68−8−4.33<0.005
L Supramarg.139−53−3543−3.56<0.005
L DLPFC105−2416433.01<0.005
R S124838−3263−4.20<0.005
    Pain intensityL PCC120−9−3342−4.43<0.005
L M1108−46−853−3.43<0.005
L IFG117−551311−3.18<0.005
L Fusiform104−32−70−9−3.05<0.005
R mPFC1331159−11−3.40<0.005
R Lingual11613−81−10−3.30<0.005
  • Hippo., Hippocampus; corr, correlations; M1, primary motor cortex; PPC, posterior parietal cortex; Supramarg., supramarginal gyrus; PAT, migraine patients; CTL, healthy controls. Other abbreviations are as defined in the text.