Table 3.

Data regarding area (nm2), perimeter (nm), and curvature (ratio) of the SAS from synapses on spines and dendritic shafts in control cases and AD patients

GroupPostsynaptic structureType of synapseArea of SAS(nm2; mean ± SEM)Perimeter of SAS (nm; mean ± SEM)Curvature of SAS (mean ± SEM)
ControlSpine headsAS14,5013 ± 41031877 ± 380.05 ± 0.001
SS81,295 ± 12,0111380 ± 1380.05 ± 0.010
Spine necksAS82,219 ± 23,4611413 ± 2550.04 ± 0.004
SS19,199 ± 0627.7 ± 00.04 ± 0
Dendritic shaftsAS115,703 ± 28451613 ± 240.04 ± 0.001
SS76,129 ± 42991442 ± 510.06 ± 0.005
AlzheimerSpine headsAS135,310 ± 47621815 ± 470.05 ± 0.002
SS50,292 ± 12,1371014 ± 1280.06 ± 0.010
Spine necksAS61,658 ± 13,2111150 ± 1190.05 ± 0.005
SS55,339 ± 01269 ± 00.11 ± 0
Dendritic shaftsAS119,272 ± 33351638 ± 320.04 ± 0.001
SS78,687 ± 58851280 ± 500.06 ± 0.005
  • All data are corrected for shrinkage factor. SEM: standard error of the mean.