Table 5.

Data regarding area (nm2), perimeter (nm), and curvature (ratio) of the SAS of macular, perforated, horseshoe-shaped, and fragmented synapses in control cases and AD patients


Group
Shape of synapsesType of synapseArea of SAS
(nm2; mean ± SEM)
Perimeter of SAS (nm; mean ± SEM)Curvature of SAS (mean ± SEM)
ControlMacularAS88,272 ± 12831352 ± 110.04 ± 0.001
SS70,960 ± 37641306 ± 400.05 ± 0.005
PerforatedAS264,960 ± 66062914 ± 580.07 ± 0.003
SS108,320 ± 22,0662080 ± 2790.07 ± 0.016
Horseshoe-shapedAS262,251 ± 13,7573725 ± 1630.09 ± 0.007
SS88,466 ± 132041876 ± 1530.06 ± 0.011
FragmentedAS360,245 ± 34,0683735 ± 4350.14 ± 0.025
SS---
AlzheimerMacularAS91,162 ± 16891367 ± 140.04 ± 0.001
SS59,436 ± 31561224 ± 420.06 ± 0.005
PerforatedAS259,540 ± 79422879 ± 730.07 ± 0.003
SS123,147 ± 14,8571776 ± 1290.03 ± 0.006
Horseshoe-shapedAS237,778 ± 95243568 ± 1270.08 ± 0.006
SS115,312 ± 0.02431 ± 00.07 ± 0.000
FragmentedAS303,922 ± 21,7832985 ± 2100.13 ± 0.014
SS---
  • All data are corrected for shrinkage factor. SEM: standard error of the mean.