Basal tonic GABA current | |||||
---|---|---|---|---|---|
n | Ihold control (pA) | Ihold PTX (pA) | RMS control (pA) | RMS PTX (pA) | |
DGGC | 5 | –68.4 ± 9.7 | –56.3 ± 8.3** | 5.2 ± 0.4 | 3.2 ± 0.2** |
PVIN | 4 | –85.9 ± 8.6 | –51.1 ± 9.8** | 7.6 ± 0.8 | 5.0 ± 0.8* |
NNC- and GABA-evoked current | |||||
n | Ihold control (pA) | Ihold NNC/GABA (pA) | RMS control (pA) | RMS NNC/GABA (pA) | |
DGGC | 12 | –67.2 ± 3.9 | –140.3 ± 11.5**** | 4.6 ± 0.1 | 12.6 ± 0.8**** |
PVIN | 11 | –147.8 ± 20.8 | 193.4 ± 21.1*** | 8.1 ± 0.7 | 11.7 ± 0.7**** |
Tonic GABA current in NNC and GABA | |||||
n | Ihold NNC/GABA (pA) | Ihold PTX (pA) | RMS NNC/GABA (pA) | RMS PTX (pA) | |
DGGC | 6 | –155.7 ± 20.7 | –59.2 ± 6.9** | 13.2 ± 1.5 | 3.6 ± 0.8** |
PVIN | 4 | –148.6 ± 23.6 | –54.5 ± 14.8** | 14.2 ± 1.0 | 6.1 ± 0.2** |
Zolpidem-evoked current | |||||
n | Ihold NNC/GABA (pA) | Ihold ZOLP (pA) | RMS NNC/GABA (pA) | RMS ZOLP (pA) | |
DGGC | 6 | –118.0 ± 8.9 | –113.7 ± 7.1 | 11.8 ± 0.7 | 11.0 ± 0.7** |
PVIN | 7 | –205.6 ± 30.2 | –229.4 ± 28.6*** | 10.2 ± 0.4 | 11.8 ± 0.7* |
n = number of neurons from a minimum of three mice per genotype. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.