Table 2.

Pharmacologically induced changes in holding current in DGGCs and PV+-INs

Basal tonic GABA current
nIhold control (pA)Ihold PTX (pA)RMS control (pA)RMS PTX (pA)
DGGC5–68.4 ± 9.7–56.3 ± 8.3**5.2 ± 0.43.2 ± 0.2**
PVIN4–85.9 ± 8.6–51.1 ± 9.8**7.6 ± 0.85.0 ± 0.8*
NNC- and GABA-evoked current
nIhold control (pA)Ihold NNC/GABA (pA)RMS control (pA)RMS NNC/GABA (pA)
DGGC12–67.2 ± 3.9–140.3 ± 11.5****4.6 ± 0.112.6 ± 0.8****
PVIN11–147.8 ± 20.8193.4 ± 21.1***8.1 ± 0.711.7 ± 0.7****
Tonic GABA current in NNC and GABA
nIhold NNC/GABA (pA)Ihold PTX (pA)RMS NNC/GABA (pA)RMS PTX (pA)
DGGC6–155.7 ± 20.7–59.2 ± 6.9**13.2 ± 1.53.6 ± 0.8**
PVIN4–148.6 ± 23.6–54.5 ± 14.8**14.2 ± 1.06.1 ± 0.2**
Zolpidem-evoked current
nIhold NNC/GABA (pA)Ihold ZOLP (pA)RMS NNC/GABA (pA)RMS ZOLP (pA)
DGGC6–118.0 ± 8.9–113.7 ± 7.111.8 ± 0.711.0 ± 0.7**
PVIN7–205.6 ± 30.2–229.4 ± 28.6***10.2 ± 0.411.8 ± 0.7*
  • n = number of neurons from a minimum of three mice per genotype. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.