Summary of the effects of MIA on female offspring alongside the male offspring from the same cohort in a previously published companion paper (Lins et al., 2018)
| Behavior test | Males | Females |
|---|---|---|
| PPI | - | - |
| MK-801 locomotion | ↑ 47.72% | n.d. |
| Sociability | ↓ 22.97% (n.s.) | ↓ 21.13% |
| Tactile memory | - | - |
| Visual memory | ↓ 90.33% | ↓ 87.87% |
| Crossmodal memory | ↓ 93.71% | - |
| Oddity preference | ↓ 31.57% | ↓ 18.69% |
↑, heightened response or facilitation; ↓, diminished response or impaired performance in comparison to a control group; –, no significant change compared to controls; n.d., not determined. Percentage change was calculated as a comparison to the equivalent control group [(saline – polyI:C/saline) × 100]. Male locomotor data were calculated from the total distance traveled after MK-801 administration. For consistency, both male and female sociability percentage change was calculated using the DR data, although it should be noted the DR was a non-significant (n.s.) effect in the males and they instead spent significantly less time (s) exploring the social stimulus than controls.