Differences in hemodynamic responses between very preterm adults and controls during easy and hard letter trials
| Condition | Region | Peak MNI coordinate [x,y,z] (mm) | Cluster size (voxels) | p value* | Contrast of parameter estimate (mean ± SD) (very preterm; control) |
|---|---|---|---|---|---|
| Easy > Rest | |||||
| Very preterm > control | Right STG, insula, thalamus | [68, –2, 4] | 3838 | <0.001 | –2.65 ± 11.71; –12.39 ± 11.21 |
| Hard > Rest | |||||
| Very preterm > control | Right STG, insula | [62, –18, –6] | 8492 | <0.001 | 0.02 ± 10.12; –11.56 ± 10.27 |
| Left STG, insula | [–54, –4, 2] | 2079 | 0.02 | –3.52 ± 13.56; –15.34 ± 10.86 | |
| Right sensorimotor cortex | [48, –40, 68] | 2013 | 0.02 | –1.54 ± 14.16; –12.71 ± 13.99 | |
| Hard > Easy | |||||
| Very preterm < control | Left LOC | [–30, –76, 45] | 2356 | 0.00567 | –3.01 ± 19.21; 9.84 ± 16.43 |
| Right LOC | [43, –82, 30] | 1944 | 0.0185 | –2.33 ± 26.59; 6.34 ± 12.06 |
*Cluster p values were obtained with z = 2.3, p < 0.05 (corrected for family wise error rate across voxels).
STG = superior temporal gyrus; LOC = lateral occipital cortex.