Various spike parameters of small (<26 µm) and large (≥26 µm) diameter DRG neurons obtained from CFA, EAE onset, and EAE chronic mice
| <26 µm | ≥26 µm | |||||
|---|---|---|---|---|---|---|
| Spike parameter | CFA | Onset | Chronic | CFA | Onset | Chronic |
| Peak amplitude (mV) | 116.4 ± 2.159 | 112.5 ± 2.437 | 116.2 ± 2.42 | 104.9 ± 1.796 | 102.2 ± 2.066 | 108.9 ± 1.362# |
| Afterhyperpolarization Amplitude (mV) | –14.38 ± 0.927 | –10.22 ± 1.223** | –13.65 ± 0.525# | –13.84 ± 0.598 | –12.18 ± 0.657 | –12.38 ± 0.483 |
| Half width (ms)& | 3.959 ± 0.421 | 5.165 ± 0.915 | 4.213 ± 0.348 | 1.18 ± 0.104 | 1.474 ± 0.141 | 1.233 ± 0.083 |
| Rise slope (mV/ms) | 175.3 ± 22.55 | 83.64 ± 6.219** | 143.1 ± 10.36## | 236.7 ± 14.12 | 108.5 ± 4.298*** | 218.8 ± 12.5### |
| Decay slope (mV/ms) | –62.46 ± 6.376 | –45.32 ± 8.131 | –55.19 ± 5.451 | –134.4 ± 5.835 | –96.5 ± 5.518*** | –120.4 ± 4.876# |
| Rheobase (nA)& | 0.2625 ± 0.017 | 0.3 ± 0.023 | 0.3074 ± 0.018 | 0.4697 ± 0.028 | 0.349 ± 0.027** | 0.4138 ± 0.022 |
Mean ± SEM. One-way ANOVA followed by Tukey’s test performed within each group; *p < 0.05, **p < 0.01, ***p < 0.001, in comparison to CFA; #p < 0.05, ##p < 0.01, ###p < 0.001 in comparison to Onset. &Graphed in Figure 6.