Table 4.

Statistical analyses performed in this study

FigureData structureStatistical testSample sizeStatistical data
1Log2-transformed to normalize dataOne-way ANOVA
(Tukey’s post hoc test)
CFA: 5
Onset: 5
Chronic: 5
A: F(2,12) = 17.78, p = 0.0003
B: F(2,12) = 4.217, p = 0.0410
C: F(2,12) = 8.126, p = 0.0059
Di: F(2,12) = 34.37, p < 0.0001
Dii: F(2,12) = 42.74, p < 0.0001
Diii: F(2,12) = 42.83, p < 0.0001
Div: F(2,12) = 9.410, p = 0.0035
2ANormalOne-way ANOVA
(Tukey’s post hoc test)
CFA: 4
Onset: 5
Chronic: 5
F(2,11) = 17.51, p = 0.0004
2BNormalOne-way ANOVA
(Tukey’s post hoc test)
CFA: 5
Onset: 5
Chronic: 3
F(2,10) = 6.254, p = 0.0173
2CNormalOne-way ANOVA
(Tukey’s post hoc test)
CFA: 4
Onset: 5
Chronic: 4
F(2,10) = 6.361, p = 0.0165
3A–CLog2-transformed to normalize dataOne-way ANOVA
(Tukey’s post hoc test)
CFA: 4
Onset: 3
Chronic: 3
A: F(2,7) = 0.9470, p = 0.4325
B: F(2,7) = 2.747, p = 0.1317
C: F(2,7) = 0.9616, p = 0.4276
3D–ILog2-transformed to normalize dataOne-way ANOVA
(Tukey’s post hoc test)
CFA: 5
Onset: 5
Chronic: 5
D: F(2,12) = 0.7474, p = 0.4944
E: F(2,12) = 1.770, p = 0.2120
F: F(2,12) = 0.8078, p = 0.4687
G: F(2,12) = 10.52, p = 0.0023
H: F(2,12) = 9.242, p = 0.0037
I: F(2,12) = 12.56, p = 0.0011
4CNon-normalTwo-tailed unpaired t test with Welch’s correctionCFA: 5
EAE: 13
t(12.41) = 3.237, p = 0.0069
5A–ELog2-transformed to normalize dataOne-way ANOVA
(Tukey’s post hoc test)
CFA: 5
Onset: 4
Chronic: 4
A: F(2,10) = 10.73, p = 0.0032
B: F(2,10) = 29.40, p < 0.0001
C: F(2,10) = 4.361, p = 0.0435
D: F(2,10) = 25.80, p = 0.0001
E: F(2,10) = 15.92, p = 0.0011
5HNormalOne-way ANOVA
(Tukey’s post hoc test)
CFA: 4
Onset: 6
Chronic: 6
F(2,13) = 7.750, p = 0.0061
6CNon-parametricKruskal–Wallis H test<26 µm:
CFA: 33
Onset: 17
Chronic: 27
≥26 µm:
CFA: 76
Onset: 51
Chronic: 94
<26 µm:
H0.5nA(2) = 0.3138, p = 0.8548
H1.0nA(2) = 0.1677, p = 0.9196
H1.5nA(2) = 0.8715, p = 0.2750
H2.0nA(2) = 0.9634, p = 0.6177
≥26 µm:
H0.5nA(2) = 1.498, p = 0.4728
H1.0nA(2) = 3.924, p = 0.1406
H1.5nA(2) = 7.448, p = 0.0241
H2.0nA(2) = 9.943, p = 0.0069
6DNormalOne-way ANOVA
(Tukey’s post hoc test)
<26 µm:
CFA: 24
Onset: 13
Chronic: 27
≥26 µm:
CFA: 76
Onset: 51
Chronic: 94
F<26µm(2,61) = 1.849, p = 0.1660
F≥26µm(2,219) = 5.274, p = 0.0058
6GNormalOne-way ANOVA
(Tukey’s post hoc test)
CFA: 24
Onset: 13
Chronic: 27
F(2,61) = 1.238, p = 0.2971
6HNormalTwo-way ANOVA (Tukey’s post hoc test)CFA: 31
Onset: 17
Chronic: 25
Disease: F(2,444) = 2.740, p = 0.0657
Spike number: F(7,444) = 25.00, p < 0.0001
Interaction: F(14,444) = 0.1811, p = 0.9996
6JNormalOne-way ANOVA
(Tukey’s post hoc test)
CFA: 76
Onset: 52
Chronic: 94
F(2,219) = 1.832, p = 0.1625
6KNormalTwo-way ANOVA (Tukey’s post hoc test)CFA: 40
Onset: 27
Chronic: 44
Disease: F(2,708) = 38.03, p < 0.0001
Spike number: F(7,708) = 11.82, p < 0.0001
Interaction: F(14,708) = 0.6171, p = 0.8522
Table 3Normal and non-normalOne-way ANOVA
(Tukey’s post hoc test) or Kruskal–Wallis H test
<26 µm:
CFA: 24
Onset: 13
Chronic: 27
≥26 µm:
CFA: 76
Onset: 51
Chronic: 94
Peak amplitude:
F<26µm(2,61) = 0.6022, p = 0.5508
F≥26µm(2,219) = 3.883, p = 0.0220
Afterhyperpolarization amplitude:
F<26µm(2,61) = 5.211, p = 0.0081
F≥26µm(2,219) = 2.481, p = 0.0860
Half width (as plotted in Fig. 6):
F<26µm(2,61) = 1.238, p = 0.2971
F≥26µm(2,219) = 1.832, p = 0.1625
Rise slope:
H<26µm(2) = 14.44, p = 0.0007
H≥26µm(2) = 50.99, p < 0.0001
Decay slope:
F<26µm(2,61) = 1.423, p = 0.2488
F≥26µm(2,219) = 10.08, p < 0.0001
Rheobase (as plotted in Fig. 6):
F<26µm(2,61) = 1.849, p = 0.1660
F≥26µm(2,219) = 5.274, p = 0.0058