Electrophysiological passive and active properties of medium spiny neurons in the core and shell of nucleus accumbens of STs, GTs, and IRs rats
| Core | Shell | |||||
|---|---|---|---|---|---|---|
| Sign-trackers | Goal-trackers | Intermediates | Sign-trackers | Goal-trackers | Intermediates | |
| Passive membrane properties | ||||||
| Resting membrane potential, mV | −81 ± 1 (23) | −80 ± 1 (17) | −81.5 ± 0.8 (31) | −82.9 ± 0.7 (19) | −79.4 ± 0.9 (23) | −80.6 ± 0.8 (15) |
| Cell capacitance, pF | 150 ± 8 (23) | 130 ± 7 (17) | 122 ± 5 (31) | 105 ± 6 (19) | 88 ± 4 (23) | 86 ± 6 (15) |
| Input resistance, MΩ | 69 ± 7 (23) | 77 ± 7 (17) | 71 ± 6 (31) | 80 ± 8 (19) | 99 ± 7 (23) | 97 ± 7 (15) |
| Active membrane properties | ||||||
| V/I curve (−500 to 0 pA) | −11.9 ± 0.2 (19) | −13.6 ± 0.2 (18) | −13.3 ± 0.2 (18) | −14.3 ± 0.3 (15) | −16.4 ± 0.2 (23) | −16.9 ± 0.3 (11) |
| V/I curve (0 to +100 pA) | 5.3 ± 0.4 (19) | 6.2 ± 0.4 (18) | 5.6 ± 0.4 (18) | 7.7 ± 0.6 (15) | 8.4 ± 0.5 (23) | 9.8 ± 0.6 (11) |
| Sag ratio at −500 pA, mV | 1.026 ± 0.003 (19) | 1.031 ± 0.003 (18) | 1.029 ± 0.003 (18) | 1.045 ± 0.004 (15) | 1.050 ± 0.002 (23) | 1.053 ± 0.006 (11) |
| Number of spikes, AP# | 4.7 ± 0.2 (23) | 6.4 ± 0.2 (17) | 5.7 ± 0.2 (31) | 6.5 ± 0.3 (19) | 7.0 ± 0.2 (23) | 8.3 ± 0.3 (15) |
| Firing frequency, Hz | 10.0 ± 0.4 (23) | 13.7 ± 0.4 (17) | 12.2 ± 0.3 (31) | 14.0 ± 0.5 (19) | 14.6 ± 0.5 (23) | 17.7 ± 0.6 (15) |
| Current to threshold, pA | 981 ± 56 (20) | 875 ± 60 (16) | 879 ± 42 (27) | 836 ± 63 (19) | 711 ± 45 (23) | 694 ± 40 (13) |
| AP threshold, mV | −45 ± 1 (20) | −44 ± 1 (16) | −45 ± 1 (27) | −45 ± 2 (19)* | −41 ± 1 (23) | −39 ± 2 (13) |
| Δ RMP/AP threshold, mV | 36 ± 2 (20) | 35 ± 1 (16) | 37 ± 8 (27) | 37 ± 2 (19) | 38 ± 1 (23) | 42 ± 2 (13) |
| AP amplitude, mV | 53.9 ± 0.9 (20) | 53 ± 1 (16) | 51 ± 1 (27) | 53 ± 1 (19) | 53 ± 2 (23) | 49 ± 2 (13) |
| Δ RMP/AP amplitude, mV | 135 ± 1 (20) | 132 ± 2 (16) | 132 ± 1 (27) | 135 ± 1 (19) | 133 ± 2 (23) | 130 ± 2 (13) |
| Δ AP threshold/AP amplitude, mV | 99 ± 2 (20) | 97 ± 2 (16) | 96 ± 2 (27) | 97 ± 2 (19)* | 94 ± 2 (23) | 88 ± 3 (13) |
| AP half-width, ms | 0.72 ± 0.02 (20)* | 0.68 ± 0.02 (16) | 0.65 ± 0.01 (27) | 0.70 ± 0.02 (19) | 0.68 ± 0.02 (23) | 0.69 ± 0.02 (13) |
Table lists mean ± SEM (sample size) for passive and active properties of core and shell MSNs for STs, GTs, and IRs. Significance for Tukey's post hoc test between STs and IRs is shown as *p < 0.05.