Computational modeling parameters and explanations
| OSN | τ = 1 ms; Vrest = −65 mV; θmin = −65 mV; θmax = −55 mV |
Unless otherwise specified, neural parameters were chosen based on previous OB models to stay consistent. All synaptic weights and threshold parameters are chosen from a uniform distribution ±10% around the average given here. Reversal potentials are based on experimental results. Time constants are meant to reproduce those reported when available θmax chosen to adjust rheobase to simulate different OXT conditions as reported in Oettl et al. (2016) |
| Mitral | τ = 5 ms; Vrest = −65 mV; θmin = −64 mV; θmax = −55 mV | |
| PG | τ = 2 ms; Vrest = −65 mV; θmin = −65 mV; θmax = −60 mV | |
| GC | τ = 4 ms; Vrest = −65 mV; θmin = −64 mV; θmax = −60 mV | |
| ET | τ = 2 ms; Vrest = −65 mV; θmin = −65 mV; θmax = −60 mV | |
| Pyr | τ = 10 ms; Vrest = −65 mV; θmin = −62 mV; θmax = −55 mV/−60 mV/−65 mV* | |
| OSN to PG | w = 0.0015; EN = +70 mV; τ1 = 1 ms; τ2 = 2 ms | |
| OSN to Mi (apical) | w = 0.015; EN = +70 mV; τ1 = 1 ms; τ2 = 2 ms | |
| OSN to ET (apical) | w = 0.0015; EN = +70 mV; τ1 = 1 ms; τ2 = 2 ms | |
| PG to Mi (apical) | w = 0.002; EN = −5 mV; τ1 = 2 ms; τ2 = 4 ms | |
| ET to Mi (apical) | w = 0.0015; EN = 70 mV; τ1 = 1 ms; τ2 = 2 ms | |
| Mi (soma) to GC | wnaive = 0.0001 EN = +70 mV; τ1 = 1 ms; τ2 = 2 ms; p = 0.25; | Chosen to reproduce reliable gamma dynamics in response to odors (Linster and Escanilla, 2019) |
| GC to Mi (soma) | w = 0.0015; EN = −10 mV; τ1 = 2 ms; τ2 = 4 ms; local only | Chosen to be local based on McIntyre and Cleland (2016) |
| Mi (soma) to Pyr | w = 0.007; EN = +70 mV; τ1 = 1 ms; τ2 = 2 ms; p = 0.20 | Adapted from de Almeida et al. (2013) to match data in Poo and Isaacson (2009); Davison and Ehlers (2011) |
| Pyr to ET | w = 0.0015; EN = +70 mV; τ1 = 1 ms; τ2 = 2 ms; p = 0.1 | |
| Pyr to GC | w = 0.0015; EN = +70 mV; τ1 = 1 ms; τ2 = 2 ms; p = 0.2 | |
| Pyr adaptation | Aahc = 10; EN = −90 mV; τahc = 100 ms | Adjusted to match data shown in McGinley and Westbrook (2011) |
τ, membrane time constant; Vrest, resting membrane potential; θmin, spiking threshold; θmax, saturation threshold; w, synaptic weight; EN, reversal potential; τ1, rise time; τ2, decay time; Aahc, afterhyperpolarization magnitude; τahc, calcium accumulation time constant.
↵* Different values are without/medium/strong OXT modulation, respectively.