Visual analysis of IA and ictal-like events (seizure activity) for each rat considered in the present study
| Rat number | 01 | 02 | 03 | 04 | 05 | 06 |
|---|---|---|---|---|---|---|
| IA bursts type | Ictal events (seizures, at D7 and at D10); Type B bursts (D7, D10) | Type A IA (D7 and D10) | Type A IA (D7); seizures at D10. | Type A bursts (D7 and D10); Type 2 IA (Type B bursts, D10); ictal events (from D7) | Type A bursts (D4, D7, and D10) | Type A bursts (D4, D7 and D10) |
| Brain regions | Seizure starting in the EC and propagating in all TL brain regions recorded (*); Type 2 IA in the hippocampus and EC | Synchronized in all TL brain regions, inversion of polarity within dorsal hippocampal layers; EC; dHPC. | EC; generalized seizures. | Seizures usually start in the EC and propagating in all TL brain regions recordeda. Type 1 IA either synchronized EC–dHPC or independently occurring in the EC and/or in the dHPC (Type A bursts); Type 2 IA in the dHPC | Synchronized in all TL brain regions, inversion of polarity within dorsal hippocampal layers; EC | dHPC and vHPC |
This analysis determines the type of IA bursts—based on the same features as the ones described in Chauvière et al. (2012)—and the seizure activity occurring along epileptogenic stages (namely, D4, D7, and D10), as well as which brain regions they involve. We note that Type B bursts occurred more prominently in two rats which have already undergone early seizure activity. The other rats have a similar pattern of (mainly Type A) IA bursts which characterizes a similar network trajectory along epileptogenesis.
↵aPlus frontal cortex in case of generalized motor seizures.