Intrinsic properties of L2/3 PNs split by control and epilepsy subtype
| Intrinsic property | Control (n = 26, 5) | MCD (n = 37, 13) | Other epilepsies (n = 45, 15) | Statistical comparison (p value) |
|---|---|---|---|---|
| Resting membrane potential (mV) | −69.98 ± 1.19 | −68.12 ± 7.13 | −67.76 ± 5.20 |
ANOVA p = 0.3464 |
| Input resistance (MΩ) | 95.21 ± 36.54 | 137.20 ± 63.21 | 111.80 ± 67.72 |
KW test p = 0.0068 |
| Voltage sag (%) | 8.42 ± 4.95 | 5.20 ± 2.34 | 5.26 ± 2.88 |
KW test p = 0.0137 |
| Membrane decay (ms) | 26.23 ± 7.95 | 26.7 ± 7.37 | 26.77 ± 7.43 |
KW test p = 0.9238 |
| AP threshold (mV) | −45.26 ± 5.61 | −35.62 ± 6.09 | −38.16 ± 4.75 |
KW test p < 0.0001 |
| AP amplitude (mV) | 84.07 ± 8.73 | 75.60 ± 8.37 | 84.64 ± 7.08 |
KW test p < 0.0001 |
| AP half-width (ms) | 1.33 ± 0.26 | 1.21 ± 0.33 | 1.38 ± 0.33 |
KW test p = 0.0064 |
| AHP magnitude (mV) | −12.87 ± 3.19 | −15.29 ± 3.19 | −14.94 ± 3.36 |
ANOVA p = 0.0102 |
| AHP latency (ms) | 10.58 ± 5.12 | 8.92 ± 6.32 | 8.65 ± 5.56 |
KW test p = 0.0843 |
| ΔAHP (mV) | −3.44 ± 3.10 | −3.86 ± 3.28 | −3.42 ± 2.73 |
KW test p = 0.9027 |
| AP broadening ratio | 1.23 ± 0.09 | 1.28 ± 0.10 | 1.25 ± 0.10 |
KW test p = 0.1324 |
| AP amplitude adaptation ratio | 0.95 ± 0.05 | 0.91 ± 0.06 | 0.94 ± 0.04 |
Welch's p = 0.0421 |
| Maximum firing rate (Hz) | 32.80 ± 10.29 | 26.68 ± 10.33 | 24.34 ± 8.10 |
ANOVA p = 0.0022 |
| Accommodation ratio | 0.46 ± 0.21 | 0.38 ± 0.16 | 0.48 ± 0.18 |
Welch's p = 0.0359 |
| Maximum depolarization slope (dV/dT) | 250.20 ± 44.25 | 211.80 ± 50.45 | 218.50 ± 48.12 |
ANOVA p = 0.0062 |
| Maximum repolarization slope (dV/dT) | −53.85 ± 14.93 | −52.61 ± 12.97 | −48.26 ± 11.89 |
KW test p = 0.0917 |
Intrinsic properties of L2/3 PNs from control, MCD and OE ex vivo brain tissue.