Adverse reaction rate between the two groups [n (%)]
| Adverse reaction | Time | The control group (n = 45) | The study group (n = 45) | p value |
|---|---|---|---|---|
| Loss of appetite | The 2nd week | 21 (46.67) | 23 (51.11) | 0.673 |
| The 12th week | 8 (17.78)a | 6 (13.33)a | 0.561 | |
| Drowsiness | The 2nd week | 20 (44.44) | 18 (40.00) | 0.670 |
| The 12th week | 2 (4.44)a | 1 (2.22)a | 0.557 | |
| Headache | The 2nd week | 7 (15.56) | 10 (22.22) | 0.419 |
| The 12th week | 0 (0.00)a | 0 (0.00)a | - | |
| Nausea and vomiting | The 2nd week | 3 (6.67) | 2 (4.44) | 0.645 |
| The 12th week | 0 (0.00) | 0 (0.00) | - | |
| Emotional instability | The 2nd week | 3 (6.67) | 3 (6.67) | >0.999 |
| The 12th week | 0 (0.00) | 1 (2.22) | 0.315 | |
| Constipation | The 2nd week | 2 (4.44) | 1 (2.22) | 0.557 |
| The 12th week | 0 (0.00) | 0 (0.00) | - |
↵a p < 0.05 versus the same group at the second week of treatment.