Table 3.

Neonatal motor behavioral task statistics

EffectsTotal motor scoreQuadruped walking scoreVertical screen scoreSurface righting scoreSurface righting timeNegative geotaxis scoreNegative geotaxis timeTactile startle scoreAuditory startle scoreForepaw grasp scoreHindpaw grasp scoreHorizontal screen scoreCliff avoidance score
Exposure (E)Wald χ2(1) = 13.975, ***p < 0.001Wald χ2(1) = 12.266, ***p < 0.001Wald χ2(1) = 0.000, p = 0.994Wald χ2(1) = 0.000, p = 1.000F(1,200) = 1.245, p = 0.266Wald χ2(1) = 0.000, p = 0.998F(1,200) = 6.660, *p = 0.011Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 0.999
Sex (S)Wald χ2(1) = 0.418, p = 0.518Wald χ2(1) = 0.140, p = 0.708Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 0.321F(1,200) = 9.424, p = 0.002Wald χ2(1) = 0.000, p = 0.999F(1,200) = 0.016, p = 0.899Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 0.999
Postnatal day (P)Wald χ2(6) = 313.444, ***p < 0.001Wald χ2(6) = 145.427, ***p < 0.001Wald χ2(6) = 19.103, **p = 0.004Wald χ2(6) = 6.998, p = 1.000F(5/2000) = 81.703, **p < 0.001Wald χ2(6) = 109.019, ***p < 0.001F(5,200) = 131.345, p < 0.0001Wald χ2(6) = 0.000, p = 1.000Wald χ2(6) = 0.000, p = 1.000Wald χ2(6) = 0.000, p = 1.000Wald χ2(6) = 0.000, p = 1.000Wald χ2(6) = 73.755, p < 0.001Wald χ2(6) = 79.290, p < 0.001
E × SWald χ2(1) = 7.355, **p = 0.007Wald χ2(1) = 0.713, p = 0.399Wald χ2(1) = 6.381, *p = 0.012Wald χ2(1) = 2.050, p = 0.152F(1,200) = 4,242, *p = 0.041Wald χ2(1) = 3.625, p = 0.057F(1,200) = 2.537, p = 0.113Wald χ2(1) = 0.000, p = 1.000Wald χ2(1) = 0.000, p = 0.997Wald χ2(1) = 0.000, p = 0.997Wald χ2(1) = 1.486, p = 0.223Wald χ2(1) = 0.909, p = 0.340Wald χ2(1) = 0.192, p = 0.661
E × PWald χ2(5) = 2.204, p = 0.820Wald χ2(5) = 4.098, p = 0.535Wald χ2(5) = 2.994, p = 0.701Wald χ2(5) = 1.882, p = 0.865F(5,200) = 2.628 *p = 0.025Wald χ2(5) = 6.054, p = 0.301F(5,200) = 0.964, p = 0.441Wald χ2(5) = 0.000, p = 1.000Wald χ2(5) = 0.000, p = 1.000Wald χ2(5) = 0.000, p = 1.000Wald χ2(5) = 1.589, p = 0.903Wald χ2(5) = 1.662, p = 0.894Wald χ2(5) = 3.515, p = 0.621
P × SWald χ2(5) = 5.999, p = 0.306Wald χ2(5) = 4.022, p = 0.546Wald χ2(5) = 2.238, p = 0.815Wald χ2(5) = 9.778, p = 0.082F(5,200) = 3.791, *p = 0.003Wald χ2(5) = 3.674, p = 0.597F(5,200) = 0.204, p = 0.961Wald χ2(5) = 0.000, p = 1.000Wald χ2(5) = 0.000, p = 1.000Wald χ2(5) = 0.000, p = 1.000Wald χ2(5) = 0.000, p = 1.000Wald χ2(5) = 1.501, p = 0.913Wald χ2(5) = 2.915, p = 0.713
E × S × PWald χ2(24) = 323.717, ***p < 0.001Wald χ2(24) = 158.526, ***p < 0.001Wald χ2(24) = 97.034, ***p < 0.001Wald χ2(24) = 50.548, **p = 0.001F(5,200) = 4.128, p = 0.001Wald χ2(24) = 154.322, ***p < 0.001F(5,200) = 1.046, p = 0.392Wald χ2(24) = 0.000, p = 1.000Wald χ2(24) = 0.958, p = 1.000Wald χ2(24) = 25.564, p = 0.376Wald χ2(24) = 0.072, p = 1.000Wald χ2(24) = 280.082, ***p < 0.001Wald χ2(24) = 97.404, ***p < 0.001
  • Statistical differences in performance on motor behavioral tasks completed by neonatal mice were determined with ordinal logistic regressions (scored behavioral tasks) or three-way ANOVAs (timed behavioral tasks). Major effects: exposure (control chow vs prenatal ethanol exposure embryonic day 13.5–16.5), sex (male vs female), and postnatal day (P2, P4, P6, P8, P10, and P14), with interactions: E × S (exposure × sex), E × P (exposure × postnatal day), P × S (postnatal day × sex), and E × S × P (exposure × sex postnatal day). Statistics with p value ≤0.05 are bolded.