Table 4.

Striatal GIN and SPN action potential (AP) characteristic statistics

EffectsGIN AP thresholdGIN AP half-widthGIN AP peak amplitudeSPN AP thresholdSPN AP half-widthSPN AP peak amplitude
Exposure (E)F(1,231) = 6.504, *p = 0.011F(1,230) = 7.020, *p = 0.019F(1,231) = 0.646, p = 0.422F(1,271) = 0.034, p = 0.853F(1,271) = 13.193, ***p < 0.001F(1,271) = 0.006, p = 0.939
Sex (S)F(1,231) = 10.088, **p = 0.002F(1,230) = 7.268, *p = 0.017F(1,231) = 0.542, p = 0.463F(1,271) = 0.016, p = 0.899F(1,271) = 0.035, p = 0.852F(1,271) = 0.397, p = 0.529
Postnatal day (P)F(3,231) = 12.869, **p < 0.001F(3,230) = 81.193, ***p < 0.001F(3,231) = 2.121, p = 0.098F(3,271) = 3.173 *p = 0.025F(3,271) = 13.813, ***p < 0.001F(3,271) = 13.990, ***p < 0.001
E × SF(1,231) = 0.976, p = 0.324F(1,230) = 12.062, ***p < 0.001F(1,231) = 0.021, p = 0.884F(1,271) = 1.698, p = 0.194F(1,271) = 1.165, p = 0.281F(1,271) = 0.980, p = 0.323
E × PF(3,231) = 3.178, *p = 0.025F(3,230) = 1.977, p = 0.118F(3,231) = 1.405, p = 0.242F(3,271) = 7.306, ***p < 0.001F(3,271) = 2.193, p = 0.089F(3,271) = 1.544, p = 0.203
P × SF(3,231) = 5.538, **p = 0.001F(3,230) = 5.826, ***p < 0.001F(3,231) = 0.300, p = 0.826F(3,271) = 0.454, p = 0.715F(3,271) = 0.326, p = 0.807F(3,271) = 1.424, p = 0.236
E × S × PF(3,231) = 3.316, *p = 0.021F(3,230) = 7.781, ***p < 0.001F(3,231) = 1.197, p = 0.312F(3,271) = 2.620, p = 0.051F(3,230) = 0.020, p = 0.996F(3,230) = 0.349, p = 0.790
  • Statistical differences in AP threshold, half-width, and peak amplitude were determined with three-way ANOVAs. Major effects: exposure (control chow vs prenatal ethanol exposure embryonic day 13.5–16.5), sex (male vs female), and postnatal day (P2, P4, P6, P8, P10, and P14), with interactions: E × S (exposure × sex), E × P (exposure × postnatal day), P × S (postnatal day × sex), and E × S × P (exposure × sex postnatal day). Statistics with p value ≤0.05 are bolded.