Table 5.

List of differentially expressed (log2fold > 1) genes in mono- and coculture astrocytes

Gene ID	avg_log2FC	p_value_adj	pct_mono	pct_co	mean_expression_mono	mean_expression_co
PTN	3.12526763	0	0.565	0.906	1.249	4.374
S100B	2.78445545	0	0.386	0.755	0.832	3.617
CRYAB	2.72380671	3.11 × 10⁻²⁶⁵	0.116	0.446	0.458	3.182
C1orf61	2.49290219	2.26 × 10⁻¹⁵⁹	0.372	0.548	1.197	3.689
TTYH1	2.39371958	0	0.566	0.81	1.218	3.612
HLA-DRA	2.27095045	6.27 × 10⁻²⁰⁴	0.059	0.304	0.499	2.770
GPM6B	2.13263619	0	0.688	0.904	1.374	3.507
SPARCL1	2.06041655	0	0.096	0.643	0.333	2.394
APOE	1.99927081	8.29 × 10⁻²³⁶	0.092	0.383	0.231	2.230
CLU	1.9895018	0	0.67	0.86	2.284	4.273
STMN2	1.896001	0	0.035	0.373	0.080	1.976
TUBB2B	1.80850987	0	0.894	0.967	2.049	3.857
METRN	1.78190413	0	0.517	0.955	0.930	2.712
MDK	1.71405259	0	0.799	0.944	1.773	3.487
SFRP2	1.67437032	4.97 × 10⁻¹⁶⁴	0.356	0.608	1.146	2.820
B2M	1.67037402	7.94 × 10⁻²³¹	0.894	0.84	2.746	4.416
PTGDS	1.63240328	1.65 × 10⁻²⁹⁹	0.026	0.314	0.065	1.698
HLA-DRB1	1.60230617	3.01 × 10⁻¹⁸⁰	0.055	0.28	0.372	1.975
LGALS3	1.57583782	1.51 × 10⁻¹²	0.542	0.473	1.181	2.757
HOPX	1.5742526	0	0.046	0.443	0.070	1.644
FABP7	1.56986694	4.64 × 10⁻²⁶⁰	0.834	0.901	2.719	4.289
HLA-DPA1	1.53158385	2.27 × 10⁻²⁰⁰	0.035	0.258	0.182	1.713
HES4	1.51028384	0	0.482	0.867	0.891	2.401
ID3	1.48419898	1.86 × 10⁻²⁵³	0.398	0.676	0.876	2.360
PPDPF	1.43624357	0	0.82	0.989	1.536	2.972
HLA-C	1.39629787	5.60 × 10⁻²⁸⁴	0.402	0.73	1.099	2.495
LY6H	1.3798325	2.68 × 10⁻²⁷⁵	0.053	0.356	0.239	1.619
NTRK2	1.37159335	0	0.2	0.634	0.613	1.984
C1QL1	1.34285	0	0.043	0.41	0.073	1.416
TUBB2A	1.32965659	0	0.739	0.879	1.529	2.859
EDNRB	1.31242052	0	0.21	0.623	0.349	1.661
IFITM3	1.31162662	9.27 × 10⁻⁵¹	0.814	0.81	2.272	3.584
PCSK1N	1.27739151	5.85 × 10⁻²²²	0.429	0.664	0.807	2.084
CRABP1	1.27257082	3.31 × 10⁻⁴³	0.12	0.239	0.835	2.107
NEFM	1.26398985	3.28 × 10⁻⁴²	0.204	0.318	0.380	1.644
BAALC	1.25243862	0	0.186	0.67	0.338	1.590
NNAT	1.21584394	0	0.001	0.326	0.001	1.217
CD74	1.21360419	1.88 × 10⁻¹⁵⁸	0.057	0.268	0.369	1.583
FABP5	1.2092159	1.42 × 10⁻¹²⁸	0.439	0.644	0.951	2.161
STMN4	1.12504838	0	0.011	0.404	0.021	1.146
NLRP1	1.12484579	0	0.37	0.761	0.657	1.782
FTH1	1.11799685	0	1	1	4.709	5.827
GPM6A	1.10542465	0	0.22	0.617	0.388	1.493
MGST3	1.09379278	0	0.749	0.934	1.376	2.470
C7orf50	1.05799363	0	0.476	0.898	0.765	1.823
HLA-DPB1	1.05573829	1.83 × 10⁻¹⁵⁹	0.035	0.227	0.161	1.217
SARAF	1.04571207	0	0.786	0.888	1.520	2.566
ITM2C	1.04499382	0	0.318	0.735	0.509	1.554
SLC1A3	1.04277099	1.48 × 10⁻²⁷⁷	0.405	0.719	0.774	1.817
A2M	1.04104507	5.23 × 10⁻⁴²	0.262	0.37	0.825	1.866
RTN1	1.03507679	3.30 × 10⁻²⁴⁸	0.043	0.31	0.075	1.110
ATP1B2	1.02804356	0	0.015	0.517	0.024	1.052
ID4	1.02743718	3.54 × 10⁻¹⁶⁷	0.43	0.647	0.821	1.849
VAMP2	1.00520525	0	0.279	0.69	0.428	1.433
IFITM1	1.00462946	6.85 × 10⁻¹⁸⁶	0.051	0.277	0.148	1.153
VCL	−1.0171318	0	0.821	0.517	1.987	0.970
FSTL1	−1.0179856	1.50 × 10⁻²⁵⁰	0.782	0.543	1.975	0.957
LRRN3	−1.0240522	0	0.648	0.226	1.381	0.357
SMS	−1.026073	0	0.838	0.561	1.943	0.917
PMEPA1	−1.0488925	6.27 × 10⁻²⁰⁷	0.584	0.283	1.526	0.478
MT-ND5	−1.0491376	0	0.999	0.963	4.097	3.048
YWHAZ	−1.0531622	0	0.992	0.885	2.795	1.742
MYH9	−1.0553458	1.26 × 10⁻²⁸⁸	0.662	0.294	1.556	0.500
PTRF	−1.0588808	8.25 × 10⁻²⁶⁷	0.632	0.268	1.567	0.508
CSRP2	−1.0641888	0	0.931	0.654	2.537	1.473
CDH2	−1.0663212	0	0.984	0.806	2.637	1.570
TPM3	−1.0851146	0	0.965	0.754	2.382	1.297
MYLK	−1.0883518	3.01 × 10⁻¹⁶⁵	0.418	0.13	1.417	0.329
TMPO	−1.1292194	1.50 × 10⁻²⁷⁸	0.686	0.324	1.853	0.724
MT-ND4L	−1.1373424	0	0.974	0.709	2.434	1.297
HNRNPU	−1.1464712	0	0.964	0.724	2.540	1.393
HNRNPAB	−1.1471103	0	0.944	0.591	2.292	1.145
HIST1H1C	−1.1843464	4.26 × 10⁻¹⁵¹	0.571	0.307	1.821	0.637
COL4A2	−1.1951134	1.85 × 10⁻²⁵⁷	0.839	0.631	2.354	1.159
HIST1H1D	−1.2114547	3.66 × 10⁻¹¹⁰	0.275	0.071	1.363	0.152
HSP90B1	−1.2156583	0	0.999	0.913	3.512	2.296
FAT1	−1.2367552	0	0.915	0.597	2.208	0.971
TLN1	−1.2530446	0	0.867	0.485	2.061	0.808
FN1	−1.2629606	6.08 × 10⁻¹¹⁰	0.399	0.164	1.788	0.525
ITGB1	−1.2650435	0	0.953	0.721	2.684	1.419
SACS	−1.2943401	0	0.854	0.364	1.861	0.566
PRSS23	−1.3034587	0	0.871	0.424	2.267	0.964
CAV1	−1.3211834	0	0.819	0.472	2.483	1.162
FILIP1L	−1.363936	0	0.565	0.117	1.558	0.194
NCL	−1.3810779	0	0.999	0.907	3.683	2.302
MYH10	−1.5078887	0	0.922	0.561	2.447	0.939
THBS1	−1.5182433	0	0.577	0.119	1.760	0.242
PALLD	−1.6739103	0	0.981	0.644	3.158	1.484
TPM4	−1.6858015	0	0.99	0.684	3.031	1.345
COL1A1	−1.6935055	5.98 × 10⁻³⁰⁰	0.802	0.31	3.850	2.156
MT-ND6	−1.7485323	0	0.944	0.391	2.402	0.653
TAGLN	−1.7788166	0	0.994	0.435	5.109	3.330
CTGF	−1.8333013	0	0.859	0.343	2.874	1.041
HIST1H1E	−1.8494481	0	0.623	0.16	2.134	0.284
IGFBP3	−1.8690066	0	0.523	0.06	2.155	0.286
SERPINE1	−1.9330432	0	0.567	0.117	2.306	0.373
TPM1	−2.037208	0	0.993	0.813	4.424	2.387
COL4A1	−2.0726514	0	0.882	0.612	3.395	1.322
ANKRD1	−2.5550829	0	0.571	0.01	2.584	0.029