Summary of comparable motor tests in Atp1A3 mouse strains
| Reference | Activity | Beam | Rotarod | Grip | Swim | Strain | |
|---|---|---|---|---|---|---|---|
| Atp1a3tm1Ling/+ | Here | = | 6N | ||||
| Moseley et al., 2007 | ↑=a | =↓f | Bl-Swiss | ||||
| DeAndrade et al., 2011 | =↓c | =↓c | = | 6N | |||
| Atp1a3+/− | Ikeda et al., 2013 | ↑ | =↑d | =f | 6J | ||
| Sugimoto et al., 2014 | = | = | =f | 6J | |||
| Sugimoto et al., 2018 | = | ||||||
| Atp1a3+/D801Y | Here | ↑ | ↓ | ↑ | ↓e | ↑ | 6N |
| Holm et al., 2016 | ↑ | 6J | |||||
| Isaksen et al., 2017 | ↓ | 6J | |||||
| Atp1a3+/I810N | Kirshenbaum et al., 2011a | ↑ | ↑ | 6N | |||
| Kirshenbaum et al., 2013 | ↓ | = | = | ↑ | 6N | ||
| Kirshenbaum et al., 2014 | ↑ | = | 6N | ||||
| Kirshenbaum et al., 2015 | ↑f | 6N | |||||
| Atp1a3+/D801N | Hunanyan et al., 2015 | ↑ | ↓ | = | = | ↑f | 6J |
| Hunanyan et al., 2021 | = | = | 6J | ||||
| Uchitel et al., 2021 | = | = | 6J | ||||
| Atp1a3+/E815K | Helseth et al., 2018 | ↓b | ↓ | ↓ | = | ?g | 6J |
This is not a comprehensive list of motor tests performed, but those most relevant for comparison here. An equals sign means no difference from WT. Up and down arrows indicate increases or decreases in performance relative to WT.
↵a Hyperactivity was seen only during the first 20 min.
↵b Hindlimb dragging.
↵c Only females were affected.
↵d There was unusually poor performance of WT given that they had 4 d of habituation.
↵e We saw qualitative differences in wire grip; see text and the more demanding rod hang test.
↵f Observations made during Morris water maze testing. The Morris water maze is used as a test of ability and memory under the implicit assumption that mice will not be abnormally fast. Published observations of swimming performance in this test in Atp1a3 mice are the most nuanced because hyperactive or thigmotaxic swimming can result in longer times to reach the platform. An up arrow in most cases was assigned because of commentary consistent with such a possibility, but please read the source papers for detail.
↵g Special case: the water was 40°C, and mice had paroxysmal spells.