Overview of functional and structural changes in glutamatergic synapses of synapsin KOs
| Genotype | Syn I KO | Syn II KO | Syn III KO | SynDKO | SynTKO | References |
|---|---|---|---|---|---|---|
| Excitability | ↑ | ↑ (↑) |
Boido et al., 2010; Farisello et al., 2013; Matos et al., 2019 (this work) | |||
| Frequency facilitation | ↓ | = | ↓ | (↓) |
Owe et al., 2009; Nikolaev and Heggelund, 2015 (this work) | |
| Depression | =↑ | =↑ | ↓ | ↑ | ↑ (↑) |
Rosahl et al., 1995; Feng et al., 2002; Gitler et al., 2004; J. Sun et al., 2006; Vasileva et al., 2012; Farisello et al., 2013 (this work) |
| PTP | =↓ | =↓ | ↓ | ↓ (↓) |
Rosahl et al., 1993, 1995; Spillane et al., 1995; Kielland et al., 2006; Valente et al., 2012; Farisello et al., 2013; Nikolaev and Heggelund, 2015; Cheng et al., 2018 (this work) | |
| LTP | = | = | (↑) |
Rosahl et al., 1993, 1995; Spillane et al., 1995; Takei et al., 1995 (this work) | ||
| Density of synaptic vesicles | ↓ | = | ↓ | ↓(↓) |
Li et al., 1995; Pieribone et al., 1995; Rosahl et al., 1995; Takei et al., 1995; Feng et al., 2002; Gitler et al., 2004; Siksou et al., 2007; Owe et al., 2009; Vasileva et al., 2012 (this work) |
Arrows indicate an increase or decrease of the properties listed in the first column, while equal signs indicate no changes. Bold symbols indicate that previous work also considered the hippocampal mossy fiber bouton. References are marked accordingly. Arrows in brackets refer to the findings of this study.