Clinical and demographic characteristics of female and male responders and nonresponders to antidepressant pharmacotherapy (mean ± SEM), and their statistical differences
| Responders (N = 33) | Nonresponders (N = 35) | Statistical difference | |||
|---|---|---|---|---|---|
| Female (N = 19) | Male (N = 14) | Female (N = 23) | Male (N = 12) | ||
| MADRS at baseline | 28.16 ± 1.00 | 28.93 ± 1.07 | 30.39 ± 1.32 | 30.00 ± 1.33 | Response: F(1,64) = 1.67, p = 0.20; sex: F(1,64) = 0.02, p = 0.88; interaction: F(1,64) = 0.21, p = 0.65 |
| MADRS at Week 2 | 18.11 ± 1.73 | 18.57 ± 1.73 | 24.48 ± 1.27 | 23.50 ± 1.78 | Response: F(1,64) = 11.61, p = 0.001; sex: F(1,64) = 0.02, p = 0.88; interaction: F(1,64) = 0.19, p = 0.66 |
| MADRS at Week 8 | 8.21 ± 1.15 | 7.07 ± 1.49 | 20.61 ± 1.09 | 22.92 ± 1.35 | Response: F(1,64) = 119.95, p < 0.001; sex: F(1,64) = 0.21, p = 0.65; Interaction: F(1,64) = 1.79, p = 0.19 |
| Age (years) | 34 ± 2.49 (19–55) | 38.36 ± 3.44 (18–59) | 34.65 ± 2.63 (18–59) | 38.58 ± 3.68 (20–59) | Response: F(1,64) = 0.02, p = 0.89; sex: F(1,64) = 1.84, p = 0.18; interaction: F(1,64) < 0.01, p = 0.94 |
| Education (years) | 17.21 ± 0.43 (14–20) | 17.29 ± 0.61 (14–20) | 16.83 ± 0.32 (14–19) | 17.50 ± 0.45 (16–20) | Response: F(1,64) = 0.04, p = 0.85; sex: F(1,64) = 0.68, p = 0.41; interaction: F(1,64) = 0.43, p = 0.51 |
| Race/ethnicitya | Black (1); East Asian (3); South Asian (1); White (15); Other | Latin American/Hispanic (1); South Asian (1); White (12); Other (1) | Black (1); East Asian (1); Jewish (1); Latin American/Hispanic (2); Southeast Asian (2); White (19); Other (1) | South Asian (1); Southeast Asian (1); White (10) | NA |
| Site | CAM (2); MCU (2); UBC (9); UCA (6) | MCU (3); QNS (3); TGH (1); UBC (4); UCA (3) | CAM (2); MCU (5); QNS (2); UBC (11); UCA (3) | MCU (3); QNS (2); UBC (3); UCA (4) | NA |
| Handedness | Left (2); right (16); ambidextrous (1) | Left (3); right (11) | Right (22); ambidextrous (1) | Left (2); right (10) | NA |
| Current marital status | Never married (11); married (5); divorced (2); domestic partnership (1) | Never married (8); separated (1); married (3); divorced (1); domestic partnership (1) | Never married (11); separated (1); married (4); divorced (2); domestic partnership (4); widowed (1) | Never married (6); separated (1); married (4); divorced (1) | NA |
MADRS, Montgomery–Åsberg Depression Rating Scale; MD, major depressive disorder; CAM, Centre for Addiction and Mental Health; MCU, McMaster University; UBC, University of British Columbia; TGH, Toronto General Hospital; QNS, Queen's University; UCA, University of Calgary, NA, not applicable.
↵a Participants were asked which of the presented race/ethnicity categories they most closely identified with. Categories were based on Canadian census questionnaires (Statistics Canada, 2006).