Table 2.

Parameters used in the closed-loop neurotoxicity model

Parameter	Value	Unit	Description
prod_Aβ	3	M ·· · years⁻¹	Production rate for Aβ
clear_Aβ	3	Years⁻¹	Clearance rate for Aβ
trans_Aβ	3	M⁻¹ ·· · years⁻¹	Transformation constant of Aβ into its toxic isoform Aβ∼
clearÃβ	2.4	Years⁻¹	Clearance rate for Aβ∼
prod_T	3	M ·· · years⁻¹	Production rate for T
clear_T	3	Years⁻¹	Clearance rate for T
trans_T	3	M⁻¹ ·· · years⁻¹	Transformation of tau into its toxic isoform T∼
clearT̃	2.55	Years⁻¹	Clearance rate for T∼
syn	0.4	M⁻² ·· ·years	Synergistic effect between Aβ∼ and T∼
ρ	50	cm ·· · years⁻¹	Effective diffusion constant
cq(Aβ∼)	1	M⁻¹ ·· · years⁻¹	Damage rate for Aβ∼
cq(T∼)	1	M⁻¹ ·· · years⁻¹	Damage rate for T∼
cq(ha)	0.01		Damage rate for hyperactivity
cexc(Aβ∼)	0.8	Years⁻¹	Constant for the effect of Aβ∼ on excitation locally
cinh(Aβ∼)	0.4	Years⁻¹	Constant for the effect of Aβ∼ on inhibition locally
cexc(T∼)	1.8	Years⁻¹	Constant for the effect of T∼ on excitatory local connectivity
cinh(T∼)	1.8	Years⁻¹	Constant for the effect of T∼ on inhibitory local connectivity
csc(T∼)	0.05	Years⁻¹	Constant for the effect of T∼ on interregional connectivity
Hemax	3.65		Maximum value allowed for H_e parameter change
Cipmin	13.25		Minimum value allowed for C_ip parameter change
Cepmin	28		Minimum value allowed for C_ep parameter change
scdam	0.3		Maximum damage of T∼ on interregional connectivity
qmax(ha)	2		Maximum damage value for hyperactivity

Note. Aβ and T stand for healthy amyloid-β and tau proteins while Aβ∼ and T∼ stand for their toxic isoforms.