Table 2.

Parameters used in the closed-loop neurotoxicity model

prod3M ·· · years−1Production rate for
clear3Years−1Clearance rate for
trans3M−1 ·· · years−1Transformation constant of into its toxic isoform Aβ
clearÃβ2.4Years−1Clearance rate for Aβ
prodT3M ·· · years−1Production rate for T
clearT3Years−1Clearance rate for T
transT3M−1 ·· · years−1Transformation of tau into its toxic isoform T
clearT̃2.55Years−1Clearance rate for T
syn0.4M−2 ·· ·yearsSynergistic effect between Aβ and T
ρ50cm ·· · years−1Effective diffusion constant
cq(Aβ)1M−1 ·· · years−1Damage rate for Aβ
cq(T)1M−1 ·· · years−1Damage rate for T
cq(ha)0.01Damage rate for hyperactivity
cexc(Aβ)0.8Years−1Constant for the effect of Aβ on excitation locally
cinh(Aβ)0.4Years−1Constant for the effect of Aβ on inhibition locally
cexc(T)1.8Years−1Constant for the effect of T on excitatory local connectivity
cinh(T)1.8Years−1Constant for the effect of T on inhibitory local connectivity
csc(T)0.05Years−1Constant for the effect of T on interregional connectivity
Hemax3.65Maximum value allowed for He parameter change
Cipmin13.25Minimum value allowed for Cip parameter change
Cepmin28Minimum value allowed for Cep parameter change
scdam0.3Maximum damage of T on interregional connectivity
qmax(ha)2Maximum damage value for hyperactivity
  • Note. and T stand for healthy amyloid-β and tau proteins while Aβ and T stand for their toxic isoforms.