Table 1.

Key reagents and resources

Reagent or resourceSourceIdentifier
Small molecules, toxins, and peptides
 D,L-AP5Tocris Biosciencecatalog #0105
 (+)-MK-801Tocris Biosciencecatalog #0924
 Nimodipine (nim)Milliporecatalog #N149
 NASPM trihydrochlorideTocris Biosciencecatalog #2766
 Cyclosporin A (CsA)Tocris Biosciencecatalog #1101
 Tacrolimus (FK506)Tocris Biosciencecatalog #3631
 Nutlin-3, racemicMilliporecatalog #444143
 Tetrodotoxin (TTX)Tocris Biosciencecatalog #1078
  Amyloid-beta (1–42) peptideAnaSpeccatalog #20276
Antibodies
 Monoclonal mouse anti-MDM2Santa Cruz Biotechnologiescatalog #sc-965 [SMP14]
 Monoclonal mouse anti-actinMilliporecatalog #MAB1501 [C4]
 Monoclonal mouse anti-GAPDHGeneTexcatalog #GTX627408 [GT239]
 Monoclonal mouse anti-PSD95BioLegendcatalog #810401 [K28/43]
 Monoclonal mouse anti-ubiquitinSanta Cruz Biotechnologiescatalog #sc-8017 [P4D1]
Recombinant plasmid DNA
 pCAG-[ctMCS] (custom “pCAGGS” backbone)gift from Dr. Matthew Kennedy
 pCAG-hAPP695(Swe-Ind)Addgenecatalog #30145
 pCAG-hAPP695(M596V)This publication
 pCMV-SGFP2-hNFATc3Wild et al., 2019
 pCMV-SGFP2-mNFATc3This publication
 pCMV-SGFP2-mNFATc3(PSAQAT)This publication
 pCMV-SGFP2-mNFATc4This publication
 pmU6-[shRNA]/“pSilencer 1.0-U6”Ambioncatalog #AM7207
 pmU6-NFATc3shRNAThis publication
 pmU6-NFATc4shRNAThis publication
 pmU6-[shRNA]-hSyn-mCh (“pFSW” lenti shuttle)gift from Dr. Jason Aoto
 pmU6-NFATc3shRNA-hSyn-mChThis publication
 pmU6-NFATc4shRNA-hSyn-mChThis publication
Experimental models and strains
 Sprague Dawley ratsCharles River Laboratoriescatalog #Crl:CD(SD)
 AKAP150ΔPIX mice (allele: AKAP5 tm1Mdaq)Sanderson et al., 2012RRID MGI_5448682
 C57BL/6J miceJackson LaboratoriesRRID IMSR_JAX:000664
Software
 SlideBook 5.5–6.03i-Intelligent Imaging Innovationshttps://www.intelligent-imaging.com/slidebook
 Fiji/ImageJ2LOCI, University of Wisconsin-Madisonhttps://imagej.net/software/fiji/
 Prism 6–8GraphPadhttps://www.graphpad.com/
 blindanalysis v1.0/blindrename.plJim Salterhttps://github.com/jimsalterjrs/blindanalysis