Summary of findings
| Method | Measure | CORT | Reelin | Ketamine |
|---|---|---|---|---|
| Behavior | FST immobility | ↑ | ↓ | ↓ |
| FST swimming | ↓ | ↑ | ↑ | |
| FST climbing | ↔ | ↔ | ↔ | |
| FST latency to immobility | ↓ | ↑ | ↔ | |
| SPT habituation | ↔ | ↔ | ↔ | |
| SPT test | ↓ | ↔ | ↔ | |
| Electrophysiology | I/O curve | ↔ | ↔ | ↔ |
| PTP | ↓ | ↔ | ↔ | |
| LTP | ↓ | ↑ | ↑ | |
| Immunohistochemistry | Reelin | ↓ | ↑ | ↑ |
| Western blotting | p-mTOR | ↔ (WH and SNP) | ↔ (WH and SNP) | ↑ (WH) ↔ (SNP) |
| mTOR | ↔ (WH and SNP) | ↔ (WH and SNP) | ↔ (WH and SNP) | |
| p-GluA1 | ↔ (WH and SNP) | ↔ (WH and SNP) | ↔ (WH and SNP) | |
| GluA1 | ↔ (WH and SNP) | ↔ (WH and SNP) | ↔ (WH and SNP) | |
| p-CREB | ↔ (WH and SNP) | ↔ (WH and SNP) | ↔ (WH and SNP) | |
| CREB | ↔ (WH and SNP) | ↔ (WH and SNP) | ↔ (WH and SNP) | |
| Synapsin I | ↔ (WH and SNP) | ↔ (WH and SNP) | ↔ (WH and SNP) | |
| PSD-95 | ↔ (WH and SNP) | ↔ (WH and SNP) | ↔ (WH and SNP) | |
| GluN2b | ↔ (WH and SNP) | ↔ (WH and SNP) | ↔ (WH and SNP) | |
| p-Erk1/2 | ↔ (WH and SNP) | ↔ (WH and SNP) | ↔ (WH and SNP) |
CORT, corticosterone; CREB, cAMP response element-binding protein; Erk1/2, extracellular signal-regulated kinase; FST, forced swim test; I/O, input/output; LTP, long-term potentiation; mTOR, mechanistic target of rapamycin; p-, phosphorylated-; PSD-95, postsynaptic density-95; PTP, post-tetanic potentiation; SPT, sucrose preference test; SNP, synaptoneurosome; WH, whole homogenate. ↑, increased; ↓, decreased; ↔, unchanged.