Table 6

The TIMP2 constructs had distinct MMP inhibitory profiles

% Inhibition	TIMP2			TIMP2-hIgG4			Ala-TIMP2
% Inhibition	10 nm	250 nm	4000 nm	10 nm	250 nm	4000 nm	10 nm	250 nm	4000 nm
MMP1	1.58	99.30	109.56	−2.28	15.96	107.23	−0.35	0.70	−6.53
MMP2	76.53	99.46	100.98	13.28	99.69	100.49	2.17	7.76	94.59
MMP3	2.80	99.44	99.14	2.06	−0.19	99.43	−0.94	−0.19	95.42
MMP7	−0.67	1.84	100.20	1.34	19.43	100.00	4.19	3.18	89.70
MMP8	9.77	99.64	100.00	6.22	2.49	100.47	−0.71	−4.97	99.53
MMP9	1.21	98.62	100.00	3.28	4.84	99.52	4.15	5.18	98.06
MMP10	−1.83	−1.22	100.19	−0.86	98.28	100.00	1.03	1.20	0.92
MMP12	2.99	97.84	79.74	0.66	4.49	81.70	2.16	−0.33	76.47
MMP13	10.17	81.33	87.89	18.11	1.29	76.65	3.33	5.36	72.03
MMP14	0.89	−2.32	99.40	−3.39	−1.25	99.60	7.62	9.33	50.00
MMP15	91.08	100.20	98.41	26.82	100.00	99.21	0.45	−1.80	98.41
MMP17	50.54	91.30	97.39	27.79	92.99	98.17	−1.82	24.16	74.15
MMP19	1.05	99.34	101.24	−7.32	42.25	100.62	0.63	7.95	22.11
MMP20	0.52	94.50	99.77	3.09	90.03	98.60	−1.20	1.89	56.28
MMP24	41.01	97.36	101.66	30.70	96.88	101.66	11.51	33.09	88.38

Percent inhibition by TIMP2, TIMP-hIgG4, and Ala-TIMP2 on 15 MMPs at three concentrations (4000 nm, 250 nm, and 10 nm).