Table 5

Summary of differential histone modifications marks and histone modifying enzymes in stress/anxiety models

MarkerSample retrievedStress modelReference
↑H4ac ↑BDNF IVPrefrontal cortexFootshock conditioned male mice (10–12 weeks) with fear extinction learning (low anxiety)Bredy et al., 2007
↓H3K9me2 ↑BDNF IVHippocampusMale rats (P21 and 2 months) subjected to maternal separationSuri et al., 2013
↑H3K9me2 ↓BDNF IVMale rats (15 months) subjected to maternal separation
↓H3K9me ↓H3K9me3HippocampusAdult male rats (P70) subjected to CRSHunter et al., 2009
↓H3K9me ↓H3K9me3Prefrontal cortexYoung female rats subjected to early maternal separation (low fear-conditioned startle)Kao et al., 2012
↑H3K9me3 ↓GRAmygdala; hippocampusAdult bHR (low anxiety) ratsChaudhury et al., 2014
↓G9a ↓H3K9me2Whole brainAdult mice treated with G9a inhibitors (low-anxiety phenotype)Wang et al., 2018
↑G9a ↑H3K9me2Nucleus accumbensViral G9a overexpression in male adult rats (high anxiety phenotype)Anderson et al., 2018
↓HDAC2 ↑HDAC3 ↓HDAC8 ↓Suv39 h1HippocampusYoung adult rats (2 months) subjected to early maternal separation (anxiety phenotype)Suri et al., 2013
↓H3K9ac ↓GR ↑CRF ↑SIRT6Amygdala (central)Male adult mice were infused with CORT (chronic anxiety)Tran et al., 2015
↓H3K9ac ↓H4K12acHippocampusAdult male rats subjected to CVSFerland and Schrader, 2011
↓HDAC5Nucleus accumbensMice subjected to CSDS (chronic anxiety)Renthal et al., 2007
↑HDAC2 ↓H3K9acAmygdala (central)Adult P rats bred for alcohol preference (anxiety phenotype)Moonat et al., 2013
  • P, postnatal day.