Comparison of behavioral phenotypes expressed by Homer2AA/AA, GRM5R/R, and GRM5AA/AA mice
| WT vs Homer2AA/AA | WT vs GRM5R/R | WT vs GRM5AA/AA | |
|---|---|---|---|
| mGlu5-coupling | ↑ (activity-dependent) | ↓ 1 (steady-state) | ↓ 3 (activity-dependent) |
| Acoustic Startle (Fig. 1; sensorimotor processing) | = | = 2 | = |
| Prepulse inhibition (PPI; Fig. 1; sensorimotor gating) | = | ↓2 | = |
| Morris water maze acquisition (Fig. 2; spatial learning) | ↑ | = | ↑ (females) = (males) |
| Morris water maze Probe test (Fig. 2; Table 1; spatial memory) | = | = | = (quadrant) ↑ (platform) |
| Morris water maze reversal training (Fig. 2; spatial reversal learning) | = | n.d. | n.d. |
| Elevated plus maze open arm time and entries (Fig. 3A,B; anxiety; agoraphobia) | ↑ | ↑2 | ↑ |
| Light-Dark box (Fig. 3C) latency and light entries (anxiety; photophobia/agoraphobia) | ↓ (latency) = (entries) | n.d. | n.d. |
| Novel object reactivity (Fig. 3D–F) latency and contacts (anxiety; neophobia/agoraphobia) | = | ↑ (latency) ↓ (contacts) | = |
| Marble burying test (Fig. 3G) latency and # buried (anxiety; neophobia) | = | n.d. | n.d. |
| Forced swim test (Fig. 3H,I) (active vs passive coping) | = | =2 | Less floating (active coping) |
| Acute cocaine locomotion (Fig. 4A) | = | = 3 | ↑ (10 mg/kg)3 |
| Sensitized cocaine locomotion (Fig. 4B) | = | = 3 | ↓ (10 and 30 mg/kg)3 |
| Dose-response function for cocaine-induced place-preference (Fig. 5A,B) | Shift to the right | No change | Shift to the left4 |
| Cocaine taste aversion (Fig. 5D,F) | ↓ | n.d. | = |