Table 2

Total brain and region weights in control and IGF-1 pigs at P5 and P9

CONIGF-1p
P5P9P5P9P5P9
Number of animals17
(F/M, 6/11)
21
(F/M, 10/11)
18
(F/M, 8/10)
21
(F/M, 13/8)
Total body weight (g)1046.3 ± 58.751203.33 ± 65.89994.17 ± 64.961285.81 ± 82.360.530.133
Total brain (g)26.58 ± 0.4030.04 ± 0.4826.50 ± 0.4430.23 ± 0.470.550.79
Total brain (%)2.66 ± 0.142.63 ± 0.132.83 ± 0.162.52 ± 0.140.290.33
Cerebrum (g)20.93 ± 0.3024.44 ± 0.4020.93 ± 0.3524.64 ± 0.420.620.72
Cerebrum (%)78.77 ± 0.5381.36 ± 0.1679.01 ± 0.3681.46 ± 0.20.850.50
Cerebellum (g)2.47 ± 0.072.72 ± 0.062.35 ± 0.052.75 ± 0.040.350.77
Cerebellum (%)9.27 ± 0.219.04 ± 0.088.86 ± 0.079.1 ± 0.120.140.77
Hippocampus (g)0.44 ± 0.020.50 ± 0.010.46 ± 0.010.51 ± 0.010.330.36
Hippocampus (%)1.67 ± 0.061.65 ± 0.041.76 ± 0.051.69 ± 0.030.400.37
Brainstem (g)2.622 ± 0.12.88 ± 0.052.58 ± 0.06a2.85 ± 0.050.420.46
Brainstem (%)9.85 ± 0.329.60 ± 0.159.79 ± 0.20a9.44 ± 0.110.480.23
Striatum (g)0.24 ± 0.010.31 ± 0.010.23 ± 0.010.31 ± 0.010.210.58
Striatum (%)0.90 ± 0.041.03 ± 0.030.86 ± 0.051.04 ± 0.030.150.59
Water content (%)84.86 ± 0.0885.20 ± 0.0985.02 ± 0.0785.02 ± 0.080.200.19
Brain/liver ratio0.918 ± 0.0570.640 ± 0.0311 ± 0.070.65 ± 0.040.160.98
  • Relative values (%) are the weight of a brain region relative to the total brain weight or total brain weight relative to body weight. Results are presented as the mean ± SEM and were analyzed using a linear model for each time point. F, Female; M, male.

  • a n = 17.