Table 1

Local genetic correlations across RSNs within the functional (FC) and structural (SC) domains

ChrStartStopRSN 1RSN 2 ρ95% CIp-value
12,215,4962,983,519FC SMNFC VN0.770.471.003.39 × 10−5
118,427,82119,238,924FC DMNFC FPN0.720.451.009.48 × 10−6
1211,082,893212,347,582FC VANFC SMN1.000.741.001.75 × 10−7
2113,930,669115,203,835FC FPNFC SMN0.880.641.003.42 × 10−7
2207,726,595208,674,588FC FPNFC VN0.970.721.001.02 × 10−6
54,636,5435,828,694FC DMNFC DAN0.730.471.002.72 × 10−5
568,006,99471,468,651FC VANFC SMN0.790.531.002.05 × 10−5
575,959,51677,290,255FC DMNFC DAN0.910.651.003.42 × 10−6
610,416,55111,790,671FC VANFC SMN0.830.551.002.49 × 10−5
750,894,50951,951,647FC LNFC VN0.880.571.005.12 × 10−6
864,215,35966,018,204FC DMNFC VN0.860.591.001.09 × 10−5
993,441,05194,175,374FC FPNFC SMN0.900.611.001.73 × 10−5
993,441,05194,175,374FC FPNFC VN0.870.621.004.58 × 10−6
1089,971,62991,021,321FC VANFC VN0.960.671.001.23 × 10−6
1539,238,84140,604,780SC DANSC FPN0.850.531.009.51 × 10−7
1713,648,44714,508,610FC DMNFC LN0.890.691.003.50 × 10−9
182,839,8433,722,828FC DMNFC DAN0.700.451.002.66 × 10−5
1917,045,96417,750,518FC LNFC DAN0.730.471.002.34 × 10−6
1917,045,96417,750,518FC DMNFC DAN0.790.531.001.43 × 10−5
  • Loci with Bonferroni-corrected significant [p < (0.05/774=) 6.46 × 10−5] rg (ρ with lower and upper limit of 95% confidence interval) between RSN-FC or RSN-SC as performed in LAVA. Within these loci, global FC or SC did not show significant univariate h2 or rg with either of the two RSNs. See Extended Data Table 1-1 for all statistics. SMN = somatomotor network, VN = visual network, DMN = default mode network, FPN = frontoparietal network, VAN = ventral attention network, DAN = dorsal attention network, LN = limbic network.