Table 4

Statistical analysis of behavioral changes after 0 or 4 weeks of UCMS with or without chronic DREADD activation of prefrontal PV+ neurons in male mice

Two-way ANOVAUCMSDREADDUCMS × DREADD
EPM
 Time in open armsF(1,32) = 6.831
p = 0.013
F(1,32) = 5.004
p = 0.032
 Entries in open arms
 Distance in open armsF(1,32) = 9.081
p = 0.005
F(1,32) = 12.40
p = 0.001
 Total distance
OF
 Time in centerF(1,32) = 7.282
p = 0.011
 Entries in centerF(1,32) = 4.154
p = 0.049
 Thigmotaxis ratioF(1,32) = 5.585
p = 0.024
 Total distanceF(1,32) = 11.47
p = 0.002
F(1,32) = 6.143
p = 0.019
CPA
 Post-Pre time in LiCl sideF(1,26) = 5.220
p = 0.031
F(1,26) = 5.039
p = 0.033
 Marble burying
 No. of marbles buriedF(1,32) = 9.285
p = 0.005
F(1,32) = 3.227
p = 0.081
 Splash test
 Time groomingF(1,26) = 7.465
p = 0.011
F(1,26) = 3.609
p = 0.068