LME analysis of SCR during trace fear recall
| CS presentation | Trace interval | US time point | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Fear recall SCR | F value | df | p-value | F value | df | p-value | F value | df | p-value |
| Drug (doxycycline/placebo) | 0.53 | 1, 94.19 | 0.468 | 2.13 | 1, 89.52 | 0.148 | 1.50 | 1, 1173.40 | 0.220 |
| Condition (CS+/CS−) | 5.55 | 1, 2774.23 | 0.019 | 5.57 | 1, 2770.09 | 0.018 | 0.56 | 1, 2745.20 | 0.455 |
| Trial number | 13.55 | 1, 94.11 | >0.001* | 38.35 | 1, 89.51 | >0.001* | 23.77 | 1, 2743.00 | >0.001* |
| Drug × Condition | 0.02 | 1, 2774.23 | 0.889 | 1.66 | 1, 2770.09 | 0.198 | 0.10 | 1, 2745.20 | 0.749 |
| Drug × Trial | 0.72 | 1, 94.11 | 0.397 | 1.58 | 1, 89.51 | 0.212 | 1.86 | 1, 2743.00 | 0.173 |
| Condition × Trial | 2.18 | 1, 2774.86 | 0.140 | 0.86 | 1, 2771.01 | 0.353 | 0.00 | 1, 2746.80 | 0.999 |
| Drug × Condition × Trial | 0.01 | 1, 2774.86 | 0.920 | 0.11 | 1, 2771.01 | 0.737 | 0.15 | 1, 2746.80 | 0.699 |
Models are estimated with lme4, lmer(data ∼ (1+trial|subject) + group*condition*trial) for CS and US time point and lmer(data ∼ (1|subject) + group*condition*trial) for trace interval, significant (p < 0.05) effects are marked with a * after Holm–Bonferroni correction.