Akaike Information Criterion (AIC), Shapiro–Wilk test (SW) for the residuals (e) and random-effects (RE) for Betti-0 (B0) and Betti-1 (B1) areas under the curve (AUC) at every developmental model
| B0-AUC | B1-AUC | |||||
|---|---|---|---|---|---|---|
| AIC | e-SW(p) | RE-SW(p) | AIC | e-SW(p) | RE-SW(p) | |
| LME-Age | 863 | 0.993 (0.71) | 0.984 (0.36) | 627.6 | 0.98 (0.04) | 0.974 (0.07) |
| LME-Age.Sex | 864.9 | 0.994 (0.82) | 0.984 (0.35) | 631.3 | 0.98 (0.04) | 0.974 (0.07) |
| GAMM-Age | 861.4 | 0.994 (0.79) | 0.987 (0.53) | 627.7 | 0.986 (0.18) | 0.981 (0.22) |
| GAMM-Age.Sex | 862.9 | 0.994 (0.82) | 0.986 (0.49) | 630.9 | 0.987 (0.21) | 0.981 (0.22) |
| GAMM-PDS | 858.3 | 0.992 (0.65) | 0.983 (0.31) | 625.6 | 0.989 (0.36) | 0.988 (0.63) |
| GAMM-PDS.Sex | 859.5 | 0.991 (0.57) | 0.979 (0.15) | 633.1 | 0.985 (0.14) | 0.984 (0.37) |
| GAMM-AgePDS | 859.4 | 0.994 (0.82) | 0.983 (0.3) | 625.9 | 0.991 (0.54) | 0.987 (0.53) |
| GAMM-AgePDS.Sex | 862.5 | 0.993 (0.74) | 0.983 (0.3) | 631.7 | 0.991 (0.57) | 0.979 (0.17) |
Developmental models: linear mixed-effects models for age (LME-Age) and age-sex interaction (LME-Age.Sex), generalized additive mixed models with smooth splines for age (GAMM-Age) and age-by-sex (GAMM-Age.Sex), PDS (GAMM-PDS) and PDS-by-sex (GAMM-PDS.Sex), and age-PDS interaction (GAMM-AgePDS) and age-PDS interaction-by-sex (GAMM-AgePDS.Sex). Akaike Information Criterion (AIC) and Shapiro–Wilk tests (SW) for the residuals (e) and random-effects (RE) of the Betti-0 (B0) and Betti-1 (B1) areas under the curve (AUC) for every developmental model.
Concerning the developmental effects at the functional network level, the PDS term showed strong effects in the fronto-parietal (FPN) and moderate effects in the auditory (AUD), sensorimotor-hand (SMH), and subcortical (SUB) networks for the B0-AUC (Fig. 5). Only the FPN had a significant effect after FDR correction (F = 6.84; EDF = 2.09; p = 0.001), which shows a nonlinear trend similar to the whole brain network (Fig. 6). No effects (even uncorrected) were found for the B1-AUC.