Highlighted genes from WGCNA shown in Figure 4
| Gene ID | logFC | p value | Gene name and citations |
|---|---|---|---|
| Slc6a2 | −1.5032 | 1.41E-05 | Norepinephrine transporter, LC enriched gene downregulated in DSP-4 mice |
| Dbh | −1.2642 | 1.81E-05 | Dopamine beta-hydroxylase, LC enriched gene downregulated in DSP-4 mice |
| Gal | −1.1636 | 4.67E-06 | Galanin, LC enriched gene downregulated in DSP-4 mice |
| Snrpg | −0.8073 | 0.0698 | Small nuclear ribonucleoprotein polypeptide G, downregulated in DSP-4 mice; potential AD biomarker (Tao et al., 2020; Du et al., 2021) |
| Fkbp1b | −0.7567 | 0.0004 | FK506 binding protein 1B, downregulated in DSP-4 mice; linked to calcium dysfunction in aging (Gant et al., 2014, 2015) |
| Slc10a4 | −0.613 | 0.0008 | Solute carrier family 10 member 4, downregulated in DSP-4 mice; possible links to AD brain pathology (Popova and Alafuzoff, 2013) |
| Rab3b | −0.4018 | 0.0141 | Ras-related protein Rab-3B, downregulated in DSP-4 mice; involved in dopamine vesicular intake |
| Gabrq | −0.2844 | 0.1076 | GABA type A receptor subunit theta, downregulated in DSP-4 mice; associated with behavioral changes in FTD (Gami-Patel et al., 2022) |
| Atad3a | 0.2154 | 0.2627 | ATPase family AAA domain containing 3A, upregulated in DSP-4 mice; potential AD biomarker (Zhao et al., 2022) |
| Tle1 | 0.3581 | 0.0351 | TLE family member 1, transcriptional corepressor, upregulated in DSP-4 mice; potential AD biomarker (Madar et al., 2021) |
| Ahr | 0.4676 | 0.1082 | Aryl hydrocarbon receptor, upregulated in DSP-4 mice; potential PD biomarker (Zhou et al., 2021) |
| Syt10 | 0.663 | 0.0335 | Synaptotagmin 10, upregulated in DSP-4 mice; provides neuroprotection after excitotoxic input (Woitecki et al., 2016) |
| Xkr8 | 0.923 | 0.0107 | XK-related 8, upregulated in DSP-4 mice; engulfs apoptotic cells |