Patients cohort
| Patients | Sex/age | Epilepsyduration | Seizurefrequency(/month) | Site(s) of SOZ | MRI | Resected area | Surgicaloutcome/follow-up | Pathology | IIS sites |
|---|---|---|---|---|---|---|---|---|---|
| 1 | F/38 | 36 | 6 | RA, RAH, REC, RPHG | R/L HA | R AMTL | IIIB/73 | HS, gliosis | RAH, RA, REC, RPHG, LA |
| 2 | F/17 | 8 | 90 | RIP, RAP, RMH | Normal | R parietotemporal neocortex | IIC/126 | Subcortical WM ectopic neurons | NA |
| 3 | F/42 | 30 | 20 | LA, LEC, LAH | L HA | L AMTL | IB/51 | FCD Ia | NA |
| 4 | F/39 | 32 | 5 | RAH, RPHG, RA, REC | R/L HA | R AMTL | IA/43 | Gliosis | RA, REC, RAH, RPHG, LA, LEC, LAH, LPHG |
| 5 | F/28 | 20 | 2 | RA, RAH, REC, RPHG | Normal | R AMTL, temporal neocortical | IVB/72 | Subcortical WM ectopic neurons | RAH, RA, RPH, LAH, REC |
| 6 | F/30 | 29 | 28 | LA, LAH | L HA | VNS | IA/12 | NA | NA |
| 7 | M/21 | 9 | 4 | REC, RAH, RPHG | R FCD, PNH | R AMTL, temporooccipital | IIIA/84 | FCD Ic, IIa | RA, REC, RAH, RPHG, RSTP, RMC, LAH |
| 8 | F/25 | 20 | 27 | RAH, RA, REC | R/L HA | R AMTL | IB/60 | None | LA, LAH, LEC, RA, RAH |
| 9 | M/42 | 22 | 16 | LEC, LPHG, LA, LAH, RAH | R/L hippocampal hyperintensity | L AMTL | II/36 | None | NA |
| 10 | F/48 | 32 | 9 | RAH, RA | Normal | R AMTL | IIIC/42 | HS | NA |
| 11 | M/40 | 5 | 1 | LA, LEC, LAH | L caudate nucleus atrophy | L AMTL | IA/24 | None | LAH, LA, LEC, RAH, RA, REC |
| 12 | F/20 | 9 | 12 | LA, LEC | Normal | L AMTL | IIB/51 | FCD IIa | NA |
| 13 | F/46 | 46 | 6 | LA, LEC, LAH | L HA | L AMTL | IB/9 | HS | NA |
| 14 | F/53 | 51 | 12 | LEC, LMH, LA | L hippocampal hyperintensity | L AMTL | IA/86 | None | LEC, LMH |
| 15 | M/45 | 5 | 8 | LEC, LMH | L HA | L AMTL | IA/58 | None | REC, RMH, LEC, LMH |
| 16 | M/29 | 8 | 13 | RA, REC, RAH, RPHG, ROFLA, LAH | Normal | RNS anterior hippocampus | IVB/25 | NA | RA, RAH, REC, RPHG, ROF, LA, LEC, LAH, LPHG, |
| 17 | F/50 | 24 | 2 | RSTA, RSTP | R perisylvian polymicrogyria | R temporoparietal neocortex, STG | IB/2 | Gliosis | RSTA, RSTP |
| 18 | F/49 | 19 | 3 | RA, REC, RMH, LA, LEC, LMH | Normal | R AMTL | IIA/61 | FCD Ic | REC, RMH, LA, LEC, LMH |
| 19 | F/41 | 12 | 30 | REC, RMH, RPHG, RSTG | Normal | R AMTL, R lateral TL | IIA/17 | HS, gliosis | REC, RMH, RPH, RSTG |
| 20 | M/49 | 31 | 20 | RA, REC, RMH, RPHG | Normal | R AMTL | IA/1.5 | FCD Ic, gliosis | RA, REC, RMH, RPHG, LA, LEC, LMH, LPHG |
| 21 | F/35 | 30 | 110 | LEC, LA, RA | L HA | VNS | IA/10 | NA | RA, RMH, LEC, LMH, LA |
| 22 | M/56 | 20 | 2 | LA, LEC | L posterior comm. artery infarct | L AMTL | IIB/27 | Subcortical WM ectopic neurons | LEC, LA |
| 23 | F/40 | 12 | 4 | RA, REC, RMH, RPHG | R FCD temporal pole | R AMTL | IB/45 | FCD IIb, gliosis | RA, REC, RMH, LA, LEC, LMH |
| 24 | F/34 | 22 | 8 | REC, RMH | Normal | R AMTL | IVC/48 | Gliosis | REC, RMH, RA |
| 25 | F/27 | 13 | 8 | LEC, LTO, LPH, REC, RMH | PVH, polymicrogyria | DBS | IVB/9 | NA | RTO, RMH, LA, LPHG |
| 26 | M/35 | 16 | 170 | REC, RMH, RPHG | Normal | Entorhinal cortex replace RNS | IIIA/29 | NA | LAH, LEC, RMH, RPHG, REC |
| 27 | F/27 | 7 | 4 | REC, RMH, RPHG, RA | Normal | RNS MTLE | IIIA/74 | NA | REC, RMH, RPHG, LMH |
| 28 | M/26 | 18 | 4 | LEC, LA, LMH, LOF, LAC, RA, REC, RMH, ROF | Encephalomalacia L lateral superior TL | TL ATL sparing mesial structures, RNS L hippocampal-LOF | IIB/20 | Gliosis, heterotopia WM | LMH, LEC, LA, LPSM, LOF, LAC, REC, RMH, RA |
| 29 | F/34 | 20 | 8 | RAH, RA, REC | R/L PNH | RNS RAH and REC | IVB/45 | NA | RAH, RA, REC, RPHG |
| 30 | M/27 | 9 | 1 | RA, REC, RPHG, LA, LEC, LMH, LPHG | R HA | RNS L/R EC | IIIA/38 | NA | RA, REC, RMH, RPHG, LA, LEC, LMH, LPHG |
| 31 | F/30 | 15 | 15 | RA, RPHG | ROF atrophy | R lesionectomy | IA/34 | Gliosis | RA, REC, RAH, RPHG, ROF, RAF, RAC |
| 32 | F/21 | 4 | 2 | LEC, LA, LMH, LPHG | L temporal pole encephalocele | L AMTL | IB/35 | HS, gliosis | LEC, LMH, RAH, REC, RPHG |
| 33 | M/51 | 23 | 4 | LEC, LAH, LPHG, REC, RPHG | R HA, L FCD | RNS L/R medial TL | IB/24 | NA | REC, RAH, RPHG, LAH, LPHG |
| 34 | M/58 | 8 | 1 | LPH, LEC, LA, RAH, REC | L HA | L AMTL | IIIA/63 | HS, gliosis | LPH, LEC, LA |
| 35 | F/49 | 13 | 3 | LA, LAH, LEC, LPHG | L hippocampal hyperintensity | RNS L medial TL and L EC | IIB/28 | NA | LAH, LEC, LA, LPHG |
| 36 | F/43 | 27 | 3 | LOF, LMH, LPHG | FCD RT pole | R AMTL, RNS L MTL–R Middle OF | IID/36 | HS | LMH, LPHG, LA, ROF |
| 37 | M/69 | 5 | 0.5 | LEC, LAH | L HA | L amygdalo-hippocampectomy w/Visualase | IIIA/55 | NA | LEC, LAH, REC, RAH |
| 38 | M/50 | 38 | 90 | LEC, LMH, LMTG, LAH, RSTG, RTP, RPT, LPT, LAH, REC | Hyperintensity L post-TL | VNS | IVB/31 | NA | RSTG, RPT, LPT, LSTG, LEC, LAH, LMTG, REC |
| 39 | F/44 | 9 | 120 | REC, RMH | R/L PNH | R AMTL | IIIA/59 | None | REC, RMH, RMNH, RPNH, RINH, LPC |
| 40 | F/34 | 8 | 5 | LEC, LA, LAH, LSTG, LPNH, LMNH, LANH | L PVH, hypothalamic hamartoma | RNS LEC-LPNH | IIB/38 | NA | LEC, LA, LAH, LPNH, LSTG |
| 41 | M/35 | 25 | 0 | RASTG, RPSTG, LSTG | Hyperintensity RT pole, PVH | R AMTL, TL R superior, middle, inferior temporal extended | IV/33 | Gliosis | RSTGA, RSTG, LSTG |
| 42 | M/25 | 15 | 8 | RMH, RSTG, RSTA, RA, REC | Atrophy R hemisphere Vascular new infarct R post-TL | R ML TL/TL R TPO, RNS RSTG, RO | IVC/12 | Gliosis, CD | REC, RSTA, RSTG, RMH, RIF, RSO, RIO, RAIP |
| 43 | M/28 | 25 | 60 | LA, LEC, LMH, RA, REC, RMH | L MTS hyperintensity amygdala R>L, L ant TL | RNS L entorhinal, L anterior insula | IIIA/33 | NA | LEC, LA, RA, REC, LOF, ROF |
R = right, L = left, A = amygdala, AH = anterior hippocampus, MH = middle hippocampus, PH = posterior hippocampus, EC = entorhinal cortex, PHG = parahippocampal gyrus, OF = orbitofrontal cortex, FA = anterior frontal, STG/A/P = superior temporal gyrus/anterior/posterior, AMTL = anteromesial temporal lobectomy, RNS = responsive neurostimulation, NA = not available, FCD = focal cortical dysplasia, HA = hippocampal atrophy, HS = hippocampal sclerosis, PNH = periventricular nodular heterotopia, TS = tuberous sclerosis. See Extended Data Table 3-1 that shows examples for resection or RNS therapy in the SOZ.