Membrane properties of CA1 pyramidal neurons across day and night in synaptic antagonists
| Day | Night | ||
|---|---|---|---|
| Mean ± SEM (n, N) | Mean ± SEM (n, N) | ||
| Baseline (mV) | Anterior | −68.41 ± 1.55 (10,6) | −67.42 ± 1.37 (11,6) |
| Posterior | −68.14 ± 1.33 (14,6) | −67.44 ± 1.38 (13,6) | |
| Input resistance (MΩ) | Anterior | 74.38 ± 5.14 (10,6) | 74.49 ± 8.76 (11,6) |
| Posterior | 74.26 ± 4.76 (14,6) | 74.28 ± 5.88 (13,6) | |
| Sag amplitude (mV) | Anterior | 6.37 ± 0.58 (10,6) | 6.37 ± 0.65 (11,6) |
| Posterior | 6.43 ± 0.54 (14,6) | 6.36 ± 0.48 (13,6) | |
| AP response slope | Anterior | 0.048 ± 0.01 (10,6) | 0.04 ± 0.015 (11,6) |
| Posterior | 0.051 ± 0.009 (14,6) | 0.059 ± 0.011 (13,6) | |
| Max (Hz) | Anterior | 18.30 ± 1.46 (10,6) | 19.55 ± 0.71 (11,6) |
| Posterior | 20.07 ± 1.05 (14,6) | 21.62 ± 1.06 (13,6) | |
| Imax (pA) | Anterior | 346.0 ± 29.22 (10,6) | 370.91 ± 14.11 (11,6) |
| Posterior | 381.43 ± 20.91 (14,6) | 407.69 ± 19.68 (13,6) | |
| Single action potential properties | |||
| Anterior | Rheobase (pA) | 132.7 ± 14.76 (10,6) | 121.82 ± 12.82 (11,6) |
| Amplitude (mV) | 93.17 ± 1.15 (10,6) | 92.885 ± 1.44 (11,6) | |
| Threshold (mV) | −40.28 ± 0.90 (10,6) | −42.15 ± 0.65 (11,6) | |
| Rise time (ms) | 0.29 ± 0.01 (10,6) | 0.32 ± 0.02 (11,6) | |
| Decay time (ms) | 1.02 ± 0.04 (10,6) | 1.01 ± 0.03 (11,6) | |
| Half-width (ms) | 0.99 ± 0.02 (10,6) | 0.98 ± 0.01 (11,6) | |
| fAHP (mV) a,b | −5.77 ± 0.74 (10,6) | −4.08 ± 0.51 (11,6) | |
| Male: −5.83 ± 0.56 (11,6) | |||
| Female: −3.98 ± 0.58 (10,6) | |||
| mAHP (mV)c | −9.29 ± 0.65 (10,6) | −7.06 ± 0.59 (11,6) | |
| Peak rise (ΔmV/Δms) | 406.80 ± 20.07 (10,6) | 397.56 ± 18.27 (11,6) | |
| Peak fall (ΔmV/Δms) | −92.16 ± 3.01 (10,6) | −91.97 ± 1.78 (11,6) | |
| Posterior | Rheobase (pA) | 126.07 ± 11.17 (14,6) | 115.23 ± 14.59 (13,6) |
| Amplitude (mV) | 92.90 ± 1.03 (14,6) | 92.07 ± 1.46 (13,6) | |
| Threshold (mV) | −40.82 ± 0.49 (14,6) | −41.01 ± 0.55 (13,6) | |
| Rise time (ms) | 0.29 ± 0.01 (14,6) | 0.28 ± 0.01 (13,6) | |
| Decay time (ms) | 1.08 ± 0.03 (14,6) | 1.04 ± 0.02 (13,6) | |
| Half-width (ms) | 1.03 ± 0.02 (14,6) | 1.00 ± 0.02 (13,6) | |
| fAHP (mV) | −5.13 ± 0.58 (14,6) | −5.72 ± 0.45 (13,6) | |
| mAHP (mV) | −8.67 ± 0.66 (14,6) | −9.65 ± 0.54 (13,6) | |
| Peak rise (ΔmV/Δms) | 390.30 ± 12.53 (14,6) | 406.47 ± 16.78 (13,6) | |
| Peak fall (ΔmV/Δms) | −86.65 ± 2.31 (14,6) | −88.15 ± 1.96 (13,6) | |