Only inhibition of MDL projecting mPFC neurons alters behavior after an error
| Parameter | Condition | MDL | MDM | eYFP (thalamus) | DMS | VMS | eYFP (striatum) |
|---|---|---|---|---|---|---|---|
| % Correct after error variable cue duration | Saline | 47.6 ± 11.81 | 40.49 ± 9.44 | 59.12 ± 11.39 | 52.98 ± 5.81 | 53.77 ± 8.52 | 65.91 ± 8.36 |
| CNO5 | 43.14 ± 14.4 | 41.1 ± 10.67 | 58.65 ± 10.28 | 51.55 ± 5.38 | 52.34 ± 11.66 | 63.66 ± 7.03 | |
| CNO10 | 38.54 ± 12.71 | 38.2 ± 13.33 | 60.59 ± 12.18 | 51.87 ± 4.23 | 49.46 ± 9.30 | 62.50 ± 6.60 | |
| Correct response latency (s) after error variable cue duration | Saline | 0.99 ± 0.22 | 1.08 ± 0.32 | 0.74 ± 0.19 | 1.24 ± 0.15 | 1.21 ± 0.31 | 1.07 ± 0.16 |
| CNO5 | 1.03 ± 0.23 | 0.99 ± 0.25 | 0.75 ± 0.19 | 1.20 ± 0.15 | 1.17 ± 0.30 | 1.06 ± 0.17 | |
| CNO10 | 1.04 ± 0.24 | 1.01 ± 0.30 | 0.72 ± 0.18 | 1.20 ± 0.14 | 1.14 ± 0.32 | 1.08 ± 0.12 | |
| % Correct after error variable delay | Saline | 56.56 ± 10.98 | 55.84 ± 8.56 | 66.11 ± 12.88 | 69.08 ± 4.41 | 59.66 ± 7.05 | 67.84 ± 9.65 |
| CNO5 | 58.69 ± 13.79 | 48.81 ± 9.29 | 68.06 ± 11.92 | 66.55 ± 5.14 | 58.81 ± 8.84 | 66.78 ± 9.89 | |
| CNO10 | 50.94 ± 13.57 | 49.74 ± 11.38 | 68.72 ± 11.58 | 65.55 ± 7.18 | 60.52 ± 7.84 | 65.62 ± 6.73 | |
| Correct response latency (s) after error variable delay | Saline | 1.02 ± 0.18 | 1.19 ± 0.30 | 0.82 ± 0.22 | 1.24 ± 0.15 | 1.31 ± 0.37 | 1.12 ± 0.18 |
| CNO5 | 1.04 ± 0.18 | 1.10 ± 0.23 | 0.83 ± 0.22 | 1.19 ± 0.16 | 1.25 ± 0.28 | 1.11 ± 0.14 | |
| CNO10 | 1.14 ± 0.19** | 1.14 ± 0.25 | 0.83 ± 0.21 | 1.17 ± 0.12 | 1.22 ± 0.29 | 1.09 ± 0.16 |
Percentage of correct responses and the correct response latency in seconds is presented in trials following error trials. Sessions in which animals received saline injections are compared with sessions where they received CNO 5 mg/kg (CNO5) or CNO 10 mg/kg (CNO10). Data are presented as mean ± SD. Interactions between thalamus (MDL/MDM/eYFP) and striatum (DMS/VMS/eYFP) groups are tested using a two-way mixed repeated measures ANOVAs with group (MDL/MDM/eYFP or DMS/VMS/eYFP) as between-subjects factor and dose as within-subjects factor. **p < 0.01 FDR-corrected paired t test versus saline. MDL n = 11, MDM n = 11, eYFP (thalamus) n = 13, DMS n = 10, VMS n = 12, eYFP (striatum) n = 13 rats. Additional data of performance after specific delay or cue duration trials are presented in Extended Data Table 1-1.