Morphine concentrations measured by tandem mass spectrometry
| Tissue | Time (h) | Total morphine ± SE |
|---|---|---|
| Maternal plasma (n = 2) | 1 | 2825.5 ± 35.0 (ng/ml) |
| Placenta (n = 7) | 1 | 2704.6 ± 99.4 (ng/g) |
| Fetal brain (n = 7) | 1 | 1267.2 ± 45.4 (ng/g) |
| Maternal plasma (n = 3) | 4 | 521.7 ± 73.6 (ng/ml) |
| Placenta (n = 11) | 4 | 415.4 ± 10.4 (ng/g) |
| Fetal brain (n = 11) | 4 | 434.0 ± 11.2 (ng/g) |
| Maternal plasma (n = 2) | 20 | <2 ng/ml |
Total morphine detected at 1, 4, and 20 h after maternal injection in maternal plasma. Tissue levels in placenta and fetal brain samples were measured at 1 and 4 h only.