Fatty acid | Mass-to-charge ratio (m/z) | Mean AUC THC/VEH | t statistic, df | Exact p value |
---|---|---|---|---|
Male NAcc PD21 | ||||
Arachidonic acid (ARA) | m/z 303.23 | 0.7916 | t = 3.137, df = 7 | 0.0139* |
Docosahexaenoic acid (DHA) | m/z 327.23 | 0.7302 | t = 6.574, df = 7 | 0.0003*** |
Adrenic acid | m/z 331.23 | 0.792 | t = 5.384, df = 7 | 0.0007*** |
Eicosatrienoic acid | m/z 305.20 | 0.73 | t = 5.643, df = 7 | 0.0005*** |
Gadoleic acid | m/z 309.25 | 0.671 | t = 5.456, df = 7 | 0.0006*** |
Linoleic acid | m/z 279.20 | 0.568 | t = 5.672, df = 7 | 0.0005*** |
Palmitic acid | m/z 255.21 | 0.632 | t = 3.669, df = 7 | 0.0063** |
Palmitoleic acid | m/z 253.19 | 0.59 | t = 3.538, df = 7 | 0.0076** |
Stearic acid | m/z 283.23 | 0.748 | t = 3.516, df = 7 | 0.0079** |
Male NAcc PD120 | ||||
Arachidonic acid (ARA) | m/z 303.23 | 0.8782 | t = 2.908, df = 11 | 0.0131* |
Docosahexaenoic acid (DHA) | m/z 327.23 | 0.8913 | t = 2.592, df = 11 | 0.0269* |
Adrenic acid | m/z 331.23 | 0.902 | t = 3.264, df = 11 | 0.0068** |
Eicosatrienoic acid | m/z 305.20 | 0.862 | t = 2.727, df = 11 | 0.0184* |
Gadoleic acid | m/z 309.25 | 1.012 | t = 0.1017, df = 11 | 0.9207 |
Linoleic acid | m/z 279.20 | 0.921 | t = 0.9614, df = 11 | 0.3553 |
Palmitic acid | m/z 255.21 | 0.878 | t = 2.221, df = 11 | 0.0463* |
Palmitoleic acid | m/z 253.19 | 0.867 | t = 2.981, df = 11 | 0.0115* |
Stearic acid | m/z 283.23 | 0.868 | t = 3.282, df = 11 | 0.0066** |
Male NAsh PD21 | ||||
Arachidonic acid (ARA) | m/z 303.23 | 0.7693 | t = 5.503, df = 7 | 0.0009*** |
Docosahexaenoic acid (DHA) | m/z 327.23 | 0.7676 | t = 3.819, df = 7 | 0.0066** |
Adrenic acid | m/z 331.23 | 0.73 | t = 4.893, df = 7 | 0.0018** |
Eicosatrienoic acid | m/z 305.20 | 0.672 | t = 7.089, df = 7 | 0.0002*** |
Gadoleic acid | m/z 309.25 | 0.494 | t = 5.256, df = 7 | 0.0012** |
Linoleic acid | m/z 279.20 | 0.649 | t = 6.087, df = 7 | 0.0005*** |
Palmitic acid | m/z 255.21 | 0.769 | t = 4.881, df = 7 | 0.0018** |
Palmitoleic acid | m/z 253.19 | 0.722 | t = 3.826, df = 7 | 0.0065** |
Stearic acid | m/z 283.23 | 0.76 | t = 5.610, df = 7 | 0.0008** |
Male NAsh PD120 | ||||
Arachidonic acid (ARA) | m/z 303.23 | 0.8931 | t = 2.908; df = 11 | 0.0131* |
Docosahexaenoic acid (DHA) | m/z 327.23 | 0.9117 | t = 1.982; df = 11 | 0.0756 |
Adrenic acid | m/z 331.23 | 0.912 | t = 0.1012; df = 11 | 0.0526 |
Eicosatrienoic acid | m/z 305.20 | 0.893 | t = 2.150; df = 11 | 0.9196 |
Gadoleic acid | m/z 309.25 | 0.994 | t = 0.1031; df = 11 | 0.0782 |
Linoleic acid | m/z 279.20 | 0.988 | t = 0.8355; df = 11 | 0.5898 |
Palmitic acid | m/z 255.21 | 0.922 | t = 1.897; df = 11 | 0.0076** |
Palmitoleic acid | m/z 253.19 | 1.084 | t = 1.497; df = 11 | 0.0280* |
Stearic acid | m/z 283.23 | 0.905 | t = 2.065; df = 11 | 0.0526 |
Female NAcc PD21 | ||||
Arachidonic acid (ARA) | m/z 303.23 | 0.8577 | t = 2.685, df = 9 | 0.025* |
Docosahexaenoic acid (DHA) | m/z 327.23 | 0.8738 | t = 3.592, df = 9 | 0.0058** |
Adrenic acid | m/z 331.23 | 0.858 | t = 3.392, df = 9 | 0.0095** |
Eicosatrienoic acid | m/z 305.20 | 0.874 | t = 1.746, df = 9 | 0.1243 |
Gadoleic acid | m/z 309.25 | 0.833 | t = 1.975, df = 9 | 0.0838 |
Linoleic acid | m/z 279.20 | 0.845 | t = 1.421, df = 9 | 0.1931 |
Palmitic acid | m/z 255.21 | 0.893 | t = 3.120, df = 9 | 0.0142* |
Palmitoleic acid | m/z 253.19 | 0.524 | t = 1.871, df = 9 | 0.0983 |
Stearic acid | m/z 283.23 | 0.857 | t = 2.872, df = 9 | 0.0208* |
Female NAcc PD120 | ||||
Arachidonic acid (ARA) | m/z 303.23 | 1.153 | t = 2.152, df = 11 | 0.0569 |
Docosahexaenoic acid (DHA) | m/z 327.23 | 1.282 | t = 1.405, df = 11 | 0.1805 |
Adrenic acid | m/z 331.23 | 1.195 | t = 1.274, df = 11 | 0.2567 |
Eicosatrienoic acid | m/z 305.20 | 1.352 | t = 1.513, df = 11 | 0.1805 |
Gadoleic acid | m/z 309.25 | 1.272 | t = 0.8198, df = 11 | 0.222 |
Linoleic acid | m/z 279.20 | 1.147 | t = 1.274, df = 11 | 0.4252 |
Palmitic acid | m/z 255.21 | 1.172 | t = 0.6142, df = 11 | 0.222 |
Palmitoleic acid | m/z 253.19 | 1.321 | t = 1.421, df = 11 | 0.1022 |
Stearic acid | m/z 283.23 | 1.056 | t = 0.9534, df = 11 | 0.5483 |
Female NAsh PD21 | ||||
Arachidonic acid (ARA) | m/z 303.23 | 0.9025 | t = 2.820, df = 9 | 0.0201* |
Docosahexaenoic acid (DHA) | m/z 327.23 | 0.871 | t = 3.370, df = 9 | 0.0083** |
Adrenic acid | m/z 331.23 | 0.871 | t = 5.995, df = 9 | 0.0002*** |
Eicosatrienoic acid | m/z 305.20 | 0.88 | t = 2.111, df = 9 | 0.061 |
Gadoleic acid | m/z 309.25 | 0.989 | t = 0.1282, df = 9 | 0.9005 |
Linoleic acid | m/z 279.20 | 0.734 | t = 3.785, df = 9 | 0.0036** |
Palmitic acid | m/z 255.21 | 0.867 | t = 1.899, df = 9 | 0.0868 |
Palmitoleic acid | m/z 253.19 | 0.923 | t = 3.332, df = 9 | 0.0088** |
Stearic acid | m/z 283.23 | 1.041 | t = 0.8969, df = 9 | 0.3931 |
Female NAsh PD120 | ||||
Arachidonic acid (ARA) | m/z 303.23 | 0.8884 | t = 1.197, df = 11 | 0.2566 |
Docosahexaenoic acid (DHA) | m/z 327.23 | 0.9297 | t = 0.6804, df = 11 | 0.5103 |
Adrenic acid | m/z 331.23 | 1.18 | t = 0.1237, df = 11 | 0.904 |
Eicosatrienoic acid | m/z 305.20 | 1.177 | t = 0.1136, df = 11 | 0.9116 |
Gadoleic acid | m/z 309.25 | 0.957 | t = 1.981, df = 11 | 0.0757 |
Linoleic acid | m/z 279.20 | 1.106 | t = 1.197, df = 11 | 0.2566 |
Palmitic acid | m/z 255.21 | 1.084 | t = 0.3331, df = 11 | 0.7453 |
Palmitoleic acid | m/z 253.19 | 1.061 | t = 0.9200, df = 11 | 0.3773 |
Stearic acid | m/z 283.23 | 1.098 | t = 1.041, df = 11 | 0.3224 |
Mass-to-charge (m/z) values obtained in Nucleus Accumbens Core (NAcc) and Nucleus Accumbens Shell (NAsh) are based on previously described mass targets (Ibrahim et al., 2017).
Area under the curve (AUC) ratio comparisons were conducted with one-sample t tests, with a hypothetical mean of 1.0, where 1.0 suggests no difference between the VEH and THC offspring; ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, two-tailed.