Cell membrane properties of M1CTX and BCTX neurons in symptomatic 75-d-old R6/2 and WT mice
| Capacitance (pF) | Input resistance (MΩ) | Time constant (ms) | |
|---|---|---|---|
| M1CTX | |||
| WT (n = 17) | 247.2 ± 15.2 | 135.9 ± 12.4 | 4.4 ± 0.3 |
| R6/2 (n = 22) | 152.8 ± 10.9*** | 293.8 ± 28.9*** | 2.8 ± 0.2*** |
| BCTX | |||
| WT (n = 17) | 193.5 ± 18.4 | 192.7 ± 23.1 | 4.1 ± 0.4 |
| R6/2 (n = 11) | 114.8 ± 9.3** | 299.1 ± 27.1** | 2.4 ± 0.2** |
Statistical significance was determined using Student’s t tests. Symbols indicate the following: **, *** represent genotype-dependent statistically significant differences between cells in each group and where p < 0.01 and p < 0.001, respectively.