Data | Data structure | Type of test | Power | Mean ± SEM | Number of cells | |
---|---|---|---|---|---|---|
Effects of DHK, UCPH101 and TBOA on the fraction of correct responses in AIIs at various stimulus frequencies | ||||||
2-Hz stimulus frequency | ||||||
Control | Non-normal distribution | 1.00 ± 0.00 | 7 | |||
200 μm DHK + 50 μm UCPH101 | Non-normal distribution | 1.00 ± 0.00 | 7 | |||
200 μm DHK + 50 μm UCPH101 + 50 μm TBOA | Normal distribution | 0.73 ± 0.08 | 7 | |||
a | Control vs DHK + UCPH | Wilcoxon signed-rank test | N/A | 7 | ||
b | DHK + UCPH vs DHK + UCPH + TBOA | Wilcoxon signed-rank test | p = 0.0313 | 7 | ||
5-Hz stimulus frequency | ||||||
Control | Non-normal distribution | 0.93 ± 0.06 | 7 | |||
200 μm DHK + 50 μm UCPH101 | Non-normal distribution | 0.94 ± 0.04 | 7 | |||
200 μm DHK + 50 μm UCPH101 + 50 μm TBOA | Normal distribution | 0.49 ± 0.12 | 7 | |||
c | Control vs DHK + UCPH | Wilcoxon signed-rank test | p > 0.9999 | 7 | ||
d | DHK + UCPH vs DHK + UCPH + TBOA | Wilcoxon signed-rank test | p = 0.0313 | 7 | ||
10-Hz stimulus frequency | ||||||
Control | Non-normal distribution | 0.96 ± 0.04 | 7 | |||
200 μm DHK + 50 μm UCPH101 | Non-normal distribution | 0.94 ± 0.04 | 7 | |||
200 μm DHK + 50 μm UCPH101 + 50 μm TBOA | Non-normal distribution | 0.27 ± 0.11 | 7 | |||
e | Control vs DHK + UCPH | Wilcoxon signed-rank test | p > 0.9999 | 7 | ||
f | DHK + UCPH vs DHK + UCPH + TBOA | Wilcoxon signed-rank test | p = 0.0156 | 7 | ||
20-Hz stimulus frequency | ||||||
Control | Non-normal distribution | 0.94 ± 0.04 | 7 | |||
200 μm DHK + 50 μm UCPH101 | Non-normal distribution | 0.94 ± 0.04 | 7 | |||
200 μm DHK + 50 μm UCPH101 + 50 μm TBOA | Normal distribution | 0.19 ± 0.03 | 7 | |||
g | Control vs DHK + UCPH | Wilcoxon signed-rank test | p > 0.9999 | 7 | ||
h | DHK + UCPH vs DHK + UCPH + TBOA | Wilcoxon signed-rank test | p = 0.0156 | 7 | ||
50-Hz stimulus frequency | ||||||
Control | Normal distribution | 0.81 ± 0.06 | 7 | |||
200 μm DHK + 50 μm UCPH101 | Normal distribution | 0.64 ± 0.08 | 7 | |||
200 μm DHK + 50 μm UCPH101 + 50 μm TBOA | Non-normal distribution | 0.16 ± 0.03 | 7 | |||
i | Control vs DHK + UCPH | Paired t test | p = 0.0533 | 7 | ||
j | DHK + UCPH vs DHK + UCPH + TBOA | Wilcoxon signed-rank test | p = 0.0156 | 7 | ||
Effects of DHK alone on the fraction of correct responses in AIIs at various stimulus frequencies | ||||||
2-Hz stimulus frequency | ||||||
Control | Non-normal distribution | 1.00 ± 0.00 | 5 | |||
200 μm DHK | Non-normal distribution | 1.00 ± 0.00 | 5 | |||
k | Control vs DHK | Wilcoxon signed-rank test | N/A | 5 | ||
5-Hz stimulus frequency | ||||||
Control | Non-normal distribution | 1.00 ± 0.00 | 5 | |||
200 μm DHK | Non-normal distribution | 1.00 ± 0.00 | 5 | |||
l | Control vs DHK | Wilcoxon signed-rank test | N/A | 5 | ||
10-Hz stimulus frequency | ||||||
Control | Non-normal distribution | 0.92 ± 0.08 | 5 | |||
200 μm DHK | Non-normal distribution | 0.92 ± 0.08 | 5 | |||
m | Control vs DHK | Wilcoxon signed-rank test | N/A | 5 | ||
20-Hz stimulus frequency | ||||||
Control | Non-normal distribution | 1.00 ± 0.00 | 5 | |||
200 μm DHK | Non-normal distribution | 1.00 ± 0.00 | 5 | |||
n | Control vs DHK | Wilcoxon signed-rank test | N/A | 5 | ||
50-Hz stimulus frequency | ||||||
Control | Non-normal distribution | 0.88 ± 0.05 | 5 | |||
200 μm DHK | Normal distribution | 0.80 ± 0.10 | 5 | |||
o | Control vs DHK | Wilcoxon signed-rank test | p = 0.5000 | 5 |
TBOA, a non-selective EAAT blocker; UCPH101, a selective EAAT1/GLAST blocker; DHK, a selective EAAT2 blocker; AII, AII amacrine cell; N/A, not applicable.