Table 7

The effects of EAAT-related drugs on the fraction of correct responses in AIIs at various light stimulus frequencies

DataData structureType of testPowerMean ± SEMNumber
of cells
Effects of DHK, UCPH101 and TBOA on the fraction of correct responses in AIIs at various stimulus frequencies
2-Hz stimulus frequency
ControlNon-normal distribution1.00 ± 0.007
200 μm DHK +
50 μm UCPH101
Non-normal distribution1.00 ± 0.007
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Normal distribution0.73 ± 0.087
aControl vs
DHK + UCPH
Wilcoxon signed-rank testN/A7
bDHK + UCPH vs DHK + UCPH + TBOAWilcoxon signed-rank testp = 0.03137
5-Hz stimulus frequency
ControlNon-normal distribution0.93 ± 0.067
200 μm DHK +
50 μm UCPH101
Non-normal distribution0.94 ± 0.047
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Normal distribution0.49 ± 0.127
cControl vs
DHK + UCPH
Wilcoxon signed-rank testp > 0.99997
dDHK + UCPH vs DHK + UCPH + TBOAWilcoxon signed-rank testp = 0.03137
10-Hz stimulus frequency
ControlNon-normal distribution0.96 ± 0.047
200 μm DHK +
50 μm UCPH101
Non-normal distribution0.94 ± 0.047
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Non-normal distribution0.27 ± 0.117
eControl vs
DHK + UCPH
Wilcoxon signed-rank testp > 0.99997
fDHK + UCPH vs DHK + UCPH + TBOAWilcoxon signed-rank testp = 0.01567
20-Hz stimulus frequency
ControlNon-normal distribution0.94 ± 0.047
200 μm DHK +
50 μm UCPH101
Non-normal distribution0.94 ± 0.047
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Normal distribution0.19 ± 0.037
gControl vs
DHK + UCPH
Wilcoxon signed-rank testp > 0.99997
hDHK + UCPH vs DHK + UCPH + TBOAWilcoxon signed-rank testp = 0.01567
50-Hz stimulus frequency
ControlNormal distribution0.81 ± 0.067
200 μm DHK +
50 μm UCPH101
Normal distribution0.64 ± 0.087
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Non-normal distribution0.16 ± 0.037
iControl vs
DHK + UCPH
Paired t testp = 0.05337
jDHK + UCPH vs DHK + UCPH + TBOAWilcoxon signed-rank testp = 0.01567
Effects of DHK alone on the fraction of correct responses in AIIs at various stimulus frequencies
2-Hz stimulus frequency
ControlNon-normal distribution1.00 ± 0.005
200 μm DHKNon-normal distribution1.00 ± 0.005
kControl vs DHKWilcoxon signed-rank testN/A5
5-Hz stimulus frequency
ControlNon-normal distribution1.00 ± 0.005
200 μm DHKNon-normal distribution1.00 ± 0.005
lControl vs DHKWilcoxon signed-rank testN/A5
10-Hz stimulus frequency
ControlNon-normal distribution0.92 ± 0.085
200 μm DHKNon-normal distribution0.92 ± 0.085
mControl vs DHKWilcoxon signed-rank testN/A5
20-Hz stimulus frequency
ControlNon-normal distribution1.00 ± 0.005
200 μm DHKNon-normal distribution1.00 ± 0.005
nControl vs DHKWilcoxon signed-rank testN/A5
50-Hz stimulus frequency
ControlNon-normal distribution0.88 ± 0.055
200 μm DHKNormal distribution0.80 ± 0.105
oControl vs DHKWilcoxon signed-rank testp = 0.50005
  • TBOA, a non-selective EAAT blocker; UCPH101, a selective EAAT1/GLAST blocker; DHK, a selective EAAT2 blocker; AII, AII amacrine cell; N/A, not applicable.