Table 4

The effects of EAAT2-related drugs on AII responses and RB membrane potentials

	Data	Data structure	Type of test	Power	Mean ± SEM	Number of cells
	Effect of DHK on AII EPSC amplitude (unit: pA)
	Control	Normal distribution			−295.40 ± 24.45	7
	200 μm DHK	Normal distribution			−350.70 ± 36.26	7
a	Control vs DHK		Paired Student’s t test	p = 0.0111		7
	Effect of GT949 on AII EPSC amplitude (unit: pA)
	Control	Normal distribution			−347.50 ± 24.07	10
	10 μm GT949	Normal distribution			−274.40 ± 24.73	10
b	Control vs GT949		Paired Student’s t test	p = 0.0004		10
	Relative effects of DHK and GT949 on AII EPSC amplitude
	Control	Non-normal distribution			1.00 ± 0.00
	200 μm DHK	Normal distribution			1.18 ± 0.04	7
	10 μm GT949	Normal distribution			0.78 ± 0.03	10
c	Control vs DHK		Wilcoxon signed-rank test	p = 0.0313		7
d	Control vs GT949		Wilcoxon signed-rank test	p = 0.0020		10
	Effect of DHK on AII EPSC time to peak (unit: ms)
	Control	Normal distribution			12.53 ± 0.44	7
	200 μm DHK	Normal distribution			11.87 ± 0.44	7
e	Control vs DHK		Paired Student’s t test	p = 0.0531		7
	Effect of DHK on AII EPSC rise time (unit: ms)
	Control	Normal distribution			3.98 ± 0.43	7
	200 μm DHK	Normal distribution			3.09 ± 0.48	7
f	Control vs DHK		Paired Student’s t test	p = 0.0050		7
	Effect of DHK on AII EPSC tau (unit: ms)
	Control	Normal distribution			6.73 ± 0.80	7
	200 μm DHK	Normal distribution			6.03 ± 0.58	7
g	Control vs DHK		Paired Student’s t test	p = 0.3519		7
	Effect of DHK on AII mEPSC frequency (unit: Hz)
	Control	Normal distribution			8.25 ± 1.20	7
	200 μm DHK	Normal distribution			8.97 ± 1.07	7
h	Control vs DHK		Paired Student’s t test	p = 0.1120		7
	Effect of DHK on AII mEPSC amplitude (unit: pA)
	Control	Normal distribution			−19.47 ± 1.30	7
	200 μm DHK	Normal distribution			−19.23 ± 0.95	7
i	Control vs DHK		Paired Student’s t test	p = 0.6892		7
	Effect of DHK on AII mEPSC rise time (unit: ms)
	Control	Normal distribution			0.33 ± 0.01	7
	200 μm DHK	Non-normal distribution			0.34 ± 0.00	7
j	Control vs DHK		Wilcoxon signed-rank test	p = 0.3750		7
	Effect of DHK on AII mEPSC tau (unit: ms)
	Control	Non-normal distribution			0.88 ± 0.06	7
	200 μm DHK	Normal distribution			0.90 ± 0.03	7
k	Control vs DHK		Wilcoxon signed-rank test	p = 0.5781		7

	Effect of DHK on RB light-evoked voltage change (unit: mV)
	Control	Normal distribution			9.62 ± 0.39	6
	200 μm DHK	Normal distribution			11.14 ± 0.56	6
l	Control vs DHK		Paired Student’s t test	p = 0.0036		6
	Effect of DHK on RB resting membrane potential (unit: mV)
	Control	Normal distribution			−55.28 ± 1.04	6
	200 μm DHK	Normal distribution			−57.21 ± 1.76	6
m	Control vs DHK		Paired Student’s t test	p = 0.1574		6

DHK, a selective EAAT2 blocker; GT949, a positive allosteric modulator of EAAT2; AII, AII amacrine cell; RB, rod bipolar cell.