Table 8

The effects of EAAT-related drugs on the average amplitude of AII EPSPs at various light stimulus frequencies

DataData structureType of testPowerMean ± SEMNumber
of cells
Effects of DHK, UCPH101 and TBOA on the average amplitude of AII EPSPs at various stimulus frequencies
2-Hz stimulus frequency
ControlNormal distribution15.75 ± 1.777
200 μm DHK +
50 μm UCPH101
Normal distribution14.62 ± 1.777
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Normal distribution5.44 ± 0.977
aControl vs
DHK + UCPH
Paired t testp = 0.17047
bDHK + UCPH vs DHK + UCPH + TBOAPaired t testp = 0.00137
5-Hz stimulus frequency
ControlNormal distribution14.58 ± 1.167
200 μm DHK +
50 μm UCPH101
Normal distribution14.36 ± 1.487
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Normal distribution5.35 ± 0.627
cControl vs
DHK + UCPH
Paired t testp = 0.78107
dDHK + UCPH vs DHK + UCPH + TBOAPaired t testp = 0.00077
10-Hz stimulus frequency
ControlNormal distribution11.90 ± 1.667
200 μm DHK +
50 μm UCPH101
Normal distribution10.74 ± 1.797
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Normal distribution2.70 ± 0.527
eControl vs
DHK + UCPH
Paired t testp = 0.07467
fDHK + UCPH vs DHK + UCPH + TBOAPaired t testp = 0.00547
20-Hz stimulus frequency
ControlNormal distribution13.41 ± 1.747
200 μm DHK +
50 μm UCPH101
Normal distribution12.45 ± 2.427
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Normal distribution4.12 ± 0.297
gControl vs
DHK + UCPH
Paired t testp = 0.49647
hDHK + UCPH vs DHK + UCPH + TBOAPaired t testp = 0.01167
50-Hz stimulus frequency
ControlNormal distribution9.99 ± 1.427
200 μm DHK +
50 μm UCPH101
Normal distribution8.67 ± 1.657
200 μm DHK +
50 μm UCPH101 + 50 μm TBOA
Non-normal distribution3.58 ± 0.247
iControl vs
DHK + UCPH
Paired t testp = 0.07637
jDHK + UCPH vs DHK + UCPH + TBOAWilcoxon signed-rank testp = 0.01567
Effects of DHK alone on the average amplitude of AII EPSPs at various stimulus frequencies
2-Hz stimulus frequency
ControlNormal distribution14.33 ± 3.615
200 μm DHKNormal distribution13.46 ± 2.415
kControl vs DHKPaired t testp = 0.63305
5-Hz stimulus frequency
ControlNormal distribution13.25 ± 1.975
200 μm DHKNormal distribution12.57 ± 1.715
lControl vs DHKPaired t testp = 0.55475
10-Hz stimulus frequency
ControlNormal distribution11.26 ± 1.875
200 μm DHKNormal distribution10.65 ± 1.555
mControl vs DHKPaired t testp = 0.43825
20-Hz stimulus frequency
ControlNormal distribution11.26 ± 0.765
200 μm DHKNormal distribution11.51 ± 1.085
nControl vs DHKPaired t testp = 0.80545
50-Hz stimulus frequency
ControlNormal distribution8.74 ± 1.075
200 μm DHKNormal distribution7.88 ± 1.055
oControl vs DHKPaired t testp = 0.07805
  • TBOA, a non-selective EAAT blocker; UCPH101, a selective EAAT1/GLAST blocker; DHK, a selective EAAT2 blocker; AII, AII amacrine cell.