Table 6

The effects of UCPH101 on AII responses

DataData structureType of testPowerMean ± SEMNumber
of cells
Effect of UCPH on AII EPSC amplitude
ControlNormal distribution−315.00 ± 22.058
50 μm UCPHNormal distribution−300.60 ± 21.528
aControl vs UCPHPaired Student’s t testp = 0.15888
Effect of UCPH on AII EPSC time to peak (unit: ms)
ControlNormal distribution14.08 ± 0.538
50 μm UCPHNormal distribution13.69 ± 0.638
bControl vs UCPHPaired Student’s t testp = 0.63068
Effect of UCPH on AII mEPSC frequency (unit: Hz)
ControlNormal distribution6.95 ± 2.248
50 μm UCPHNormal distribution7.22 ± 2.378
cControl vs UCPHPaired Student’s t testp = 0.46858
DHK effect on AII mEPSC amplitude (unit: pA)
ControlNormal distribution−21.62 ± 0.788
50 μm UCPHNormal distribution−19.94 ± 0.828
dControl vs UCPHPaired Student’s t testp = 0.07078
Effect of UCPH on AII mEPSC rise time (unit: ms)
ControlNon-normal distribution0.32 ± 0.018
50 μm UCPHNormal distribution0.32 ± 0.018
eControl vs UCPHWilcoxon signed-rank testp = 0.81258
Effect of UCPH on AII mEPSC tau (unit: ms)
ControlNormal distribution0.75 ± 0.048
50 μm UCPHNormal distribution0.76 ± 0.038
fControl vs UCPHPaired Student’s t testp = 0.63828
  • UCPH101, a selective EAAT1/GLAST blocker; AII, AII amacrine cell.