Intrinsic electrophysiological properties of CA1 pyramidal neurons
| WT (n = 7 cells from 5 mice) | Het (n = 10 cells from 7 mice) | p value (unpaired t test) | |
|---|---|---|---|
| Resting membrane potential (mV) | −60.59 ± 1.83 | −58.40 ± 1.61 | 0.385 |
| Input resistance (MΩ) | 136.60 ± 16.90 | 118.00 ± 10.34 | 0.335 |
| Membrane time constant (ms) | 17.19 ± 2.12 | 12.64 ± 6.06 | 0.138 |
| Capacitance (pF) | 132.00 ± 13.6 | 112.10 ± 18.00 | 0.428 |
| Voltage sag (mV) | 5.81 ± 0.52 | 6.72 ± 0.44 | 0.190 |
| Rheobase (pA) | 153.60 ± 24.7 | 140.00 ± 13.50 | 0.611 |
| Voltage threshold (mV) | −39.22 ± 1.70 | −38.25 ± 1.05 | 0.617 |
| 1st spike rise time (μs) | 269.40 ± 21.21 | 255.50 ± 22.68 | 0.674 |
| 1st spike half width (ms) | 1.49 ± 0.12 | 1.36 ± 0.09 | 0.375 |