Table 3

Summary and overview of experimentally reported propagation speeds, DC shift amplitudes (DC) and their duration (DC dur.), peak in extracellular K⁺ levels (Peak [K+]e ), duration of increased relative changes in mean fluorescence (ΔFF dur.), alteration in neuronal volume fractions (Δαn) and their duration (Δαn dur.), and alteration in the ECS volume fractions (Δαe) during CSD from a selection of studies in either WT mice [Study (WT)] or AQP4 knock-out mice [Study (AQP4– /–)] measured (M) in vivo (IV) or in slices (S)

						ΔFF dur.
		Speed	DC	DC dur.	Peak [K+]e	ΔFF dur.	Δα_n	Δα_n dur.	Δα_e
		(mm/min)	(mV)	(s)	(mm)	(s)	(%)	(min)	(%)
Study (WT)	M
Lauritzen and Hansen (1992)	IV	3.8 ± 0.9	23 ± 6
Theis et al. (2003)	S	3.8 ± 0.4	16.8 ± 1.1	58 ± 15	38.6 ± 3
–	–	4.4 ± 0.3
Padmawar et al. (2005)	IV	4.4 ± 0.5
Takano et al. (2007)	IV			66 ± 4			37.1 ± 0.1	8 – 10
Chang et al. (2010)	IV		18.5	68
Zhou et al. (2010)	S	1.56 ± 0.24^†					11.0 ± 0.9^§	5 – 7
Thrane et al. (2013)	IV		18.71 ± 2.11		75.54 ± 1.86
Enger et al. (2015)	IV	3.34 ± 0.1		66.4 ± 3.8		18.6 ± 1.7
Yao et al. (2015)	IV	3.70 ± 0.1	22 ± 1.8	31 ± 2.4*	34.3 ± 0.8				70.6^**
–	–			48 ± 4.8*
Enger et al. (2017)	IV	4.60 ± 0.2		66.7 ± 10.1		19.5 ± 1.3
Kucharz et al. (2017)	IV		12.44 ± 0.65
Study (AQP4^{– /–})	M
Thrane et al. (2013)	IV		12.80 ± 1.16		64.49 ± 1.73
Yao et al. (2015)	IV	2.90 ± 0.1	19.6 ± 1.4	38 ± 3.6*	35.5 ± 0.7				72.6^**
–	–			58 ± 2.4*
Enger et al. (2017)	IV	4.60 ± 0.2		86.0 ± 13.3		15.7 ± 1.2

* Duration measured at half-maximum amplitude; † speed reported in experiments with TTX, indicated to be 50% of the CSD wave speed without TTX; § deviation from baseline of high [K+]e perfusion; ** baseline ECS volume fraction differs between WT mice (0.18) and AQP4^{– /–} mice (0.23).