Mouse genetic mutant lines and control genotypes used in each figure
| Figure | Abbreviation | KO mice | Source | Genotype of control groups | Comment | |
|---|---|---|---|---|---|---|
| Fig. 3 | DKO | Trh KO mice | Yamada et al. (1997) | Trh+/− or −/−; Oxt+/− or −/− | +/* means +/+ or +/− | |
| Oxt KO mice | JAX (#2713) | |||||
| Fig. 4 | QKO | Avpr 1a KO mice | JAX (#5776) | All other genotypes besides Avpr1a−/−; Avpr1b−/−; Trh−/−; Oxt−/− (Fig. 4C) | ||
| Avpr 1b KO mice | JAX (#6160) | Avpr1a+/− or −/−; Avpr1b+/−; Trh+/− or −/−; Oxt+/− or −/− (Fig. 4D) | ||||
| Trh KO mice | Yamada et al. (1997) | Avpr1a+/−; Avpr1b+/− or −/−; Trh+/− or −/−; Oxt+/− or −/− (Fig. 4E) | ||||
| Oxt KO mice | JAX (#2713) | Avpr1a+/− or −/−; Avpr1b+/− or −/−; Trh+/−; Oxt+/− or −/− (Fig. 4F) | ||||
| Avpr1a+/− or −/−; Avpr1b+/− or −/−; Trh+/− or −/−; Oxt+/− (Fig. 4G) | ||||||
| Fig. 5 | TKO | Avpr 1a KO mice | JAX (#5776) | All other genotypes besides Avpr1a−/−; Avpr1b−/−; Oxtr−/− (Fig. 5C) | ||
| Avpr 1b KO mice | JAX (#6160) | Avpr1a+/−; Avpr1b+/−; Oxtr+/− (Fig. 5D) | ||||
| Oxtr KO mice | Takayanagi et al. (2005) | Avpr1a+/− or −/−; Avpr1b+/−; Oxtr+/− or −/− (Fig. 5E) | ||||
| Avpr1a+/−; Avpr1b+/− or −/−; Oxtr+/− or −/− (Fig. 5F) | ||||||
| Avpr1a+/− or −/−; Avpr1b+/− or −/−; Oxtr+/− (Fig. 5G) | ||||||
| Fig. 6 | TKO | Avpr 1a KO mice | JAX (#5776) | Avpr1a+/−; Avpr1b+/−; Oxtr+/− | ||
| Avpr 1b KO mice | JAX (#6160) | |||||
| Oxtr KO mice | Takayanagi et al. (2005) | |||||
| Fig. 7 | TKO | Avpr 1a KO mice | JAX (#5776) | All other genotypes besides Avpr1a−/−; Avpr1b−/−; Oxtr−/− (Fig. 7B) | ||
| Avpr 1b KO mice | JAX (#6160) | Avpr1a+/−; Avpr1b+/−; Oxtr+/− (Fig. 7C) | ||||
| Oxtr KO mice | Takayanagi et al. (2005) | Avpr1a+/− or −/−; Avpr1b+/−; Oxtr+/− or −/− (Fig. 7D) | ||||
| Avpr1a+/−; Avpr1b+/− or −/−; Oxtr+/− or −/− (Fig. 7E) | ||||||
| Avpr1a+/− or −/−; Avpr1b+/− or −/−; Oxtr+/− (Fig. 7F) | ||||||
| Fig. 8 | HIR | Avpr1a and 1b DKO mice | Kumamoto University (#559) | Avpr1a+/−; Avpr1b+/−; Oxtr+/− | JAX (#5776) Avpr1a KO line was not a null mutation, Kumamoto (#599) Avpr1a KO line has been confirmed for the phenotype in cardiovascular system | |
| Oxtr KO mice | Takayanagi et al. (2005) | |||||
| Fig. 9 | TKO | Avpr 1a KO mice | JAX (#5776) | Avpr1a+/− or −/−; Avpr1b+/−; Oxtr+/− or −/− (Fig. 9B) | ||
| Avpr 1b KO mice | JAX (#6160) | Avpr1a+/−; Avpr1b+/− or −/−; Oxtr+/− or −/− (Fig. 9C) | ||||
| Oxtr KO mice | Takayanagi et al. (2005) | Avpr1a+/− or −/−; Avpr1b+/− or −/−; Oxtr+/− (Fig. 9D) | ||||
| Fig. 10 | TKO | Avpr 1a KO mice | JAX (#5776) | Avpr1a+/−; Avpr1b+/−; Oxtr+/− (large panels) | ||
| Avpr 1b KO mice | JAX (#6160) | Avpr1a+/− or −/−; Avpr1b+/− or −/−; Oxtr+/− (small left panels) | ||||
| Oxtr KO mice | Takayanagi et al. (2005) | Avpr1a+/−; Avpr1b+/− or −/−; Oxtr+/− or −/− (small middle panels) | ||||
| Avpr1a+/− or −/−; Avpr1b+/−; Oxtr+/− or −/− (small right panels) | ||||||