Table 6

Identification of a shared NSC gene signature enriched in juvenile/adult SGZ NSCs relative to embryonic SGZ RPs and juvenile/adult SGZ IPs (related to Fig. 8-10)

Genes upregulated in juvenile/adult SGZ NSCs
vs E16.5 DG RPsvs juvenile/adult SGZ IPs
GeneAverage logFCAdjusted p valueAverage log FCAdjusted p value
2310022B05Rik*1.012.63E-041.127.80E-10
4930402H24Rik*0.912.40E-020.862.70E-03
Acsbg1*0.944.70E-030.881.66E-03
Acsl6*0.925.81E-030.881.40E-03
Aldoc*0.794.73E-032.641.17E-34
Ank21.309.97E-080.892.89E-04
Apoe*2.163.11E-371.848.67E-40
Appl21.298.71E-081.076.96E-08
Arhgap5*0.883.88E-020.852.19E-05
Atp1a2*1.971.84E-301.753.13E-33
Atp1b2*1.661.29E-171.723.98E-24
Bhlhe41*1.054.41E-030.874.46E-02
Chchd10*1.204.37E-061.054.14E-07
Clu*1.176.96E-091.801.88E-23
Cmtm5*1.355.95E-121.046.21E-09
Cpe*1.656.97E-191.141.68E-13
Cspg5*0.955.26E-031.391.87E-14
Csrp1*1.091.64E-040.865.50E-03
Cst3*2.539.43E-411.772.06E-39
Cxcl14*1.033.12E-021.051.87E-05
Dbp*0.905.80E-030.791.99E-02
Dclk1*1.271.96E-100.937.08E-07
Dtna*1.472.85E-111.263.46E-11
Entpd2*0.934.31E-021.164.62E-09
Fam107a*1.131.35E-061.054.22E-07
Fxyd1*1.654.67E-141.569.34E-17
Gabrb1*1.152.04E-051.461.34E-15
Gfap*1.316.72E-071.243.09E-10
Gja1*1.773.01E-131.452.59E-13
Gm10561*1.701.98E-121.357.80E-10
Gm2a*1.041.66E-020.882.74E-03
Gm3764*0.581.26E-030.863.85E-11
Gnao1*0.943.64E-041.037.22E-09
Gpm6a*1.691.55E-231.484.40E-25
Gpm6b*1.251.69E-231.341.41E-29
Gpr37l1*1.659.83E-171.361.22E-13
Gria21.901.39E-230.991.39E-12
Gstm1*1.838.38E-221.818.69E-29
Hepacam*1.236.10E-070.881.90E-02
Hopx1.383.68E-131.727.54E-24
Hopxos0.743.39E-020.704.23E-02
Id4*1.581.08E-101.644.10E-17
Itih3*1.601.24E-131.488.70E-15
Itm2c*0.981.98E-041.081.66E-09
Kcnj10*1.161.21E-050.991.72E-06
Lgr41.201.86E-041.054.53E-03
Lsamp*1.542.22E-121.306.65E-12
Malat1*1.529.63E-331.122.07E-27
Mfge8*0.977.49E-101.304.72E-20
Mgll*1.021.52E-030.961.32E-05
Mlc1*1.201.48E-061.429.39E-16
Mmd2*0.753.13E-071.031.70E-15
Msi2*1.317.15E-100.681.13E-02
Mt1*2.481.36E-362.675.99E-45
Mt2*1.652.14E-212.096.21E-34
Mt3*1.681.84E-302.539.75E-46
Neat1*1.291.82E-061.147.61E-06
Notch21.973.39E-091.742.44E-11
Nrxn1*1.851.53E-200.987.26E-09
Nrxn2*1.251.40E-070.893.74E-04
Ntm*1.451.78E-081.211.58E-07
Ntrk2*1.612.17E-211.635.14E-27
Ntsr2*1.971.26E-181.514.64E-14
Ogt*1.192.72E-060.833.69E-04
Padi21.412.91E-091.281.96E-09
Phkg1*0.879.90E-030.825.55E-03
Pitpnc1*1.018.58E-040.843.62E-05
Pla2g7*1.031.53E-021.076.67E-05
Plpp3*1.856.41E-301.714.37E-34
Prex2*1.673.28E-161.411.60E-16
Prnp*1.324.53E-091.082.60E-09
Psap*1.222.34E-121.169.57E-15
Ptprz1*1.559.55E-311.431.16E-32
Qk*0.801.54E-061.088.16E-17
Ramp1*1.273.03E-071.247.79E-10
Riiad1*1.291.02E-041.392.04E-10
Rsrp1*1.041.21E-061.033.30E-10
S100a1*1.612.13E-151.321.38E-14
S100a16*1.773.24E-181.342.48E-15
S100a6*1.203.61E-061.163.61E-08
S1pr1*1.333.43E-071.361.67E-12
Scarb2*0.963.92E-030.781.59E-03
Scd2*1.363.83E-201.354.04E-24
Scg3*0.929.73E-030.807.60E-04
Sdc4*1.498.05E-071.432.84E-10
Selm*1.021.12E-030.852.95E-05
Sepp1*1.052.97E-050.771.99E-03
Sfxn5*2.131.16E-141.701.27E-13
Sirpa*1.051.84E-031.022.00E-06
Slc14a10.903.74E-040.891.47E-05
Slc1a2*3.391.71E-402.223.72E-41
Slc1a3*1.922.94E-401.801.38E-44
Slc25a181.364.21E-101.233.79E-11
Slc6a1*1.343.20E-061.082.00E-04
Slc6a11*1.501.40E-121.214.39E-10
Sox9*0.997.59E-071.361.22E-16
Sparcl1*2.179.21E-241.721.27E-23
St6galnac51.121.10E-051.036.65E-06
Syt11*0.922.17E-121.182.88E-21
Timp3*0.996.78E-030.984.02E-06
Tmem47*1.623.77E-171.561.00E-21
Tpcn1*0.872.01E-020.776.07E-03
Tsc22d4*0.954.13E-051.303.73E-15
Tspan7*1.696.08E-261.685.68E-31
Ttyh1*1.093.38E-101.932.61E-29
  • Differential gene expression was performed for (1) juvenile/adult SGZ NSCs (P18–P132; blue cells in two final right panels in Fig. 3C) versus E16.5 SGZ RPs (blue cells in left panel in Fig. 3C) and (2) juvenile/adult SGZ NSCs versus juvenile/adult SGZ IPs (P18–P132; 139 cells). This analysis identified 105 genes that were significantly enriched in juvenile/adult SGZ NSCs relative to both E16.5 SGZ RPs and juvenile/adult SGZ IPs (log fold change > 0.5, adj. p value < 0.05; FWER). These 105 genes are shown along with their fold change in expression and adjusted p values. Also indicated with an asterisk are 94 of these genes that were also enriched in juvenile/adult V-SVZ dormant NSCs relative to E14 V-SVZ RPs and juvenile/adult V-SVZ TAPs, as identified in Borrett et al. (2020). These 94 genes were used to define a shared adult dormant NSC gene signature. Analysis using this 94 gene signature is described in Figures 8-10.