Table 5

Gene sets positively correlated with time, as analyzed by GSEA for total SGZ NSCs from E16.5 to P132 (related to Fig. 6)

PathwayAdj.
p value (FDR)
Norm. Enr.
score
nMore-
Extreme
SizeCategory
IONOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAY%GOBP%GO:00352359.84E-032.46015Neurotransmitter/synaptic regulation
CELLULAR RESPONSE TO STEROL%GOBP%GO:00363159.84E-032.46015Signaling
NEUROTRANSMITTER UPTAKE%GOBP%GO:00015041.01E-022.49016Neurotransmitter/synaptic regulation
EXPORT ACROSS PLASMA MEMBRANE%GOBP%GO:01401151.01E-022.23016Membrane transport + ion balance
REGULATION OF MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS%GOBP%GO:00510431.03E-022.32017Miscellaneous
NEGATIVE REGULATION OF PEPTIDYL-THREONINE PHOSPHORYLATION%GOBP%GO:00108011.03E-022.21017Miscellaneous
ACIDIC AMINO ACID TRANSPORT%GOBP%GO:00158001.30E-022.75027Membrane transport + ion balance
REGULATION OF TRIGLYCERIDE METABOLIC PROCESS%GOBP%GO:00902071.37E-022.22029Metabolism (lipid)
SODIUM ION TRANSMEMBRANE TRANSPORT%GOBP%GO:00357251.41E-022.43030Membrane transport + ion balance
IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P000371.49E-022.43032Neurotransmitter/synaptic regulation
NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.51.51E-022.46034Neurotransmitter/synaptic regulation
RESPONSE TO DIETARY EXCESS%GOBP%GO:00020211.68E-022.25115IR
POSITIVE REGULATION OF ANION TRANSPORT%GOBP%GO:19037931.76E-022.29039Membrane transport + ion balance
ZINC ION HOMEOSTASIS%GOBP%GO:00550691.78E-022.09118Membrane transport + ion balance
SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P057341.78E-022.09118Neurotransmitter/synaptic regulation
EXPLORATION BEHAVIOR%GOBP%GO:00356401.95E-022.01123IR
REGULATION OF BONE RESORPTION%GOBP%GO:00451241.95E-022.00123IR
MATING%GOBP%GO:00076181.95E-021.94123IR
CYTOKINE SECRETION%GOBP%GO:00506631.95E-021.92123Membrane transport + ion balance
REGULATION OF SYNAPTIC TRANSMISSION, GLUTAMATERGIC%GOBP%GO:00519662.05E-022.14049Neurotransmitter/synaptic regulation
IMPORT ACROSS PLASMA MEMBRANE%GOBP%GO:00987392.32E-022.35053Membrane transport + ion balance
NEUROMUSCULAR PROCESS CONTROLLING BALANCE%GOBP%GO:00508852.32E-021.92053IR
EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.22.41E-021.94219Metabolism (lipid)
OLIGODENDROCYTE DIFFERENTIATION%GOBP%GO:00487092.42E-022.20056Gliogenesis
POSITIVE REGULATION OF AMINE TRANSPORT%GOBP%GO:00519542.48E-022.17134Membrane transport + ion balance
POSTSYNAPTIC MEMBRANE ORGANIZATION%GOBP%GO:00019412.57E-021.89222Neurotransmitter/synaptic regulation
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-HSA-425393.22.64E-022.38062Membrane transport + ion balance
ION HOMEOSTASIS%REACTOME%R-HSA-5578775.12.64E-021.93136Membrane transport + ion balance
ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 71%9368372.64E-021.89136Membrane transport + ion balance
POSITIVE REGULATION OF LIPID BIOSYNTHETIC PROCESS%GOBP%GO:00468892.67E-022.12063Metabolism (lipid)
REGULATION OF COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 71%9776062.70E-021.98315Signaling
REGULATION OF GLYCOPROTEIN METABOLIC PROCESS%GOBP%GO:19030182.71E-022.25137Metabolism
REPRODUCTIVE BEHAVIOR%GOBP%GO:00190982.74E-021.99226IR
INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.12.82E-021.95317Miscellaneous
RESPONSE TO COPPER ION%GOBP%GO:00466882.82E-021.89317Membrane transport + ion balance
CELLULAR POTASSIUM ION TRANSPORT%GOBP%GO:00718042.83E-022.56067Membrane transport + ion balance
PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 71%67943622.83E-022.04067Neurotransmitter/synaptic regulation
LONG-CHAIN FATTY ACID METABOLIC PROCESS%GOBP%GO:00016762.88E-022.19140Metabolism (lipid)
ADENYLATE CYCLASE-INHIBITING G PROTEIN-COUPLED RECEPTOR SIGNALING PATHWAY%GOBP%GO:00071932.90E-021.95229Signaling
PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY2.90E-021.89320Signaling
RESPONSE TO ZINC ION%GOBP%GO:00100432.90E-021.89320Membrane transport + ion balance
POSITIVE REGULATION OF STEROID METABOLIC PROCESS%GOBP%GO:00459402.90E-021.87320Metabolism
AMINO ACID TRANSPORT%GOBP%GO:00068652.96E-022.54072Membrane transport + ion balance
NEGATIVE REGULATION OF CELL-SUBSTRATE ADHESION%GOBP%GO:00108123.09E-021.85144Miscellaneous
NEUROTRANSMITTER METABOLIC PROCESS%GOBP%GO:00421333.15E-021.83145Neurotransmitter/synaptic regulation
REGULATION OF BEHAVIOR%GOBP%GO:00507953.15E-021.73145IR
GLYCOSPHINGOLIPID METABOLIC PROCESS%GOBP%GO:00066873.23E-021.87234Metabolism (lipid)
REGULATION OF ANION TRANSPORT%GOBP%GO:00440703.27E-022.02076Membrane transport + ion balance
DRUG TRANSPORT%GOBP%GO:00158933.37E-022.22078Membrane transport + ion balance
OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 71%4498363.58E-021.86516Signaling
BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY3.69E-021.88424Signaling
OLIGOSACCHARIDE METABOLIC PROCESS%GOBP%GO:00093113.81E-021.74425Metabolism
PLASMA LIPOPROTEIN PARTICLE ORGANIZATION%GOBP%GO:00718273.81E-021.89518Miscellaneous
GLIAL CELL DEVELOPMENT%GOBP%GO:00217823.83E-021.84086Gliogenesis
REGULATION OF CELL-MATRIX ADHESION%GOBP%GO:00019523.83E-021.76086Extracellular matrix
ACYLGLYCEROL METABOLIC PROCESS%GOBP%GO:00066393.87E-021.82155Metabolism (lipid)
ADENYLATE CYCLASE-MODULATING G PROTEIN-COUPLED RECEPTOR SIGNALING PATHWAY%GOBP%GO:00071883.87E-021.71083Signaling
SIGNALING BY NTRK2 (TRKB)%REACTOME%R-HSA-9006115.23.96E-021.85521Signaling
RESPONSE TO MECHANICAL STIMULUS%GOBP%GO:00096124.36E-021.53091IR
MYELINATION%GOBP%GO:00425524.42E-021.98094Gliogenesis
MULTICELLULAR ORGANISMAL SIGNALING%GOBP%GO:00356374.43E-021.63166Signaling
UNSATURATED FATTY ACID METABOLIC PROCESS%GOBP%GO:00335594.51E-021.81433Metabolism (lipid)
MEMBRANE ASSEMBLY%GOBP%GO:00717094.58E-021.88528Miscellaneous
RESPONSE TO AMINO ACID%GOBP%GO:00432004.58E-021.68168Miscellaneous
ANION TRANSMEMBRANE TRANSPORT%GOBP%GO:00986564.71E-022.01097Membrane transport + ion balance
SYNAPSE ASSEMBLY%GOBP%GO:00074164.71E-021.66170Neurotransmitter/synaptic regulation
ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 71%9837124.78E-021.65096Membrane transport + ion balance
REGULATION OF CELL JUNCTION ASSEMBLY%GOBP%GO:19018884.94E-021.71173Miscellaneous
RESPONSE TO CADMIUM ION%GOBP%GO:00466864.96E-021.86627Membrane transport + ion balance
RECEPTOR-MEDIATED ENDOCYTOSIS%GOBP%GO:00068984.96E-021.820101Membrane transport + ion balance
GPCRS, OTHER%WIKIPATHWAYS_20191210%WP41%MUS MUSCULUS4.96E-021.79627Signaling
  • Shown are gene sets that are positively correlated with time (increasing in the transition from embryonic RPs to adult NSCs) where FDR < 0.05, analyzed from the combined SGZ RP/NSC dataset (a total of 885 cells, cells highlighted in blue in Fig. 3C). Also shown are the adjusted p values (adj. p value; FDR), enrichment scores (Norm. Enr. score), the size of the gene set and the number of times a random gene set had a more extreme enrichment score than the gene set (nMoreExtreme). Gene sets are ordered from most to least significant from top to bottom. These gene sets were also categorized with regard to a number of broad categories, including neurotransmitter transport and synaptic regulation (neurotransmitter/synaptic regulation), ion regulation and membrane transport (ion balance + membrane transport), signaling pathways (signaling), gliogenesis and metabolism and lipid oxidation (metabolism). IR indicates they were not considered relevant to the NSCs and miscellaneous includes gene sets that do not fit into these categories.