Table 2

Full list of blood parameters over time

Param	Unit	Group 1 (baseline)			Group 2 (implant ≤3 years)			Group 3 (implant >3 years)			KW	Paired tests (groups)
Param	Unit	Mean	SD	N	Mean	SD	N	Mean	SD	N		1–2	1–3	2–3
Hemogram
Leukocytes	G/l	8.38	2.6	20	9.62	2.95	25	10.19	3.66	27	n.s.	-	-	-
Erythrocytes	T/l	5.56	0.44	19	5.54	0.41	25	5.73	0.44	27	n.s.	-	-	-
Hemoglobin	g/l	131.71	7.49	20	131.46	9.8	25	135.55	12	27	n.s.	-	-	-
Hematocrit	%	40.86	2.81	20	41.85	2.82	25	42.81	3.94	27	n.s.	-	-	-
MCV	fl	73.95	4.29	19	75.64	4.3	25	74.89	4.81	27	n.s.	-	-	-
MCH	pg	23.96	1.46	19	24.1	1.21	25	23.75	1.61	27	n.s.	-	-	-
MCHC	g/dl	32.45	1.25	19	31.83	1.04	25	31.74	0.99	27	n.s.	-	-	-
Thrombocytes	G/l	369.76	76.29	19	354.43	77.13	25	354.17	101.16	27	n.s.	-	-	-
Differential
Basophils	%	0.11	0.31	20	0	0	25	0.07	0.21	27	n.s.	-	-	-
Eosinophils	%	1.38	1.43	20	1.65	1.34	25	1.45	0.99	27	n.s.	-	-	-
Lymphocytes	%	45.53	18.33	20	39.61	13.69	25	34.02	14.24	27	n.s.	-	-	-
Monocytes	%	3.41	2.6	20	3.6	1.77	25	4.36	2.26	27	n.s.	-	-	-
Neutrophils	%	45.82	21.4	20	54.63	13.56	25	57.59	18.8	27	n.s.	-	-	-
T3	μg/l	1.82	0.43	18	2.15	0.63	24	1.82	0.59	25	n.s.	-	-	-
D3	nmol/l	171.01	48.96	16	156	75.16	23	147.42	44.23	23	n.s.	-	-	-
Electrophoresis
Albumin	g/l	44.7	2.86	5	44.23	2.2	5	44.13	4.32	17	n.s.	-	-	-
α1-globulin	g/l	2.67	0.41	6	2.47	0.32	6	2.66	0.64	17	n.s.	-	-	-
α2-globulin	g/l	8	2	6	8.94	2.46	6	9.17	1.73	17	n.s.	-	-	-
β-globulin	g/l	7.75	2.52	6	8.62	1.89	6	10.13	1.82	17	n.s.	-	-	-
γ-globulin	g/l	7.58	3.64	6	6.81	3.23	6	10.04	2.45	17	n.s.	-	-	-
Chloride	mmol/l	108.32	1.98	17	106.6	2.9	24	107.49	2.64	26	n.s.	-	-	-
Iron	μmol/l	25.21	6.57	19	24.04	5.75	25	23.96	12.02	27	n.s.	-	-	-
Geriatric profile
T4	μg/dl	4.44	1.25	18	4.43	1.31	24	4.87	1.28	26	n.s.	-	-	-
Kidney
Urea	mg/dl	21.97	6.89	18	19.67	5.56	25	18.03	5.53	26	n.s.	-	-	-
Creatinine	μmol/l	69.4	17.81	20	77.69	12.65	25	82.46	14.56	27	n.s.	-	-	-
Total protein	g/l	69.76	8.6	20	75.53	6.36	25	75.25	14.74	27	n.s.	-	-	-
Sodium	mmol/l	149.07	2.92	19	147.16	3.59	25	148.71	3.31	27	n.s.	-	-	-
Potassium	mmol/l	3.91	0.27	19	3.98	0.35	25	3.96	0.45	27	n.s.	-	-	-
Phosphates	mmol/l	1.56	0.35	19	1.44	0.33	25	1.32	0.29	27	n.s.	-	-	-
Liver
Bilirubin	μmol/l	2.69	0.78	20	2.9	1.08	25	3.2	1.23	27	n.s.	-	-	-
ALT	U/l	84.27	88.26	19	63.75	41.24	25	80.67	104.23	27	n.s.	-	-	-
AP	U/l	420.52	204.04	19	339.6	208.56	25	216.23	81.65	27	**	n.s.	***	**
γ-GT	U/l	75.47	27.08	19	68.39	22.04	25	60.16	23.5	27	n.s.	-	-	-
AST	U/l	43.92	17.04	19	38.15	24.1	25	31.17	14.2	27	n.s.	-	-	-
GLDH	U/l	38.58	46.8	19	20.75	13.24	25	36.7	53.69	27	n.s.	-	-	-
Serum albumin	g/l	43.06	7.37	19	44.07	4.29	25	40.22	8.02	27	n.s.	-	-	-
Pancreas
Glucose	mmol/l	4.82	1.34	20	4.38	1.06	25	4.66	1.34	27	n.s.	-	-	-
α-Amylase	U/l	468.11	105.71	19	495.52	119.96	25	461.74	144.65	27	n.s.	-	-	-
Lipase	U/l	22.34	6.72	18	18.55	3.47	25	20.18	7.36	27	n.s.	-	-	-
Cholesterol	mmol/l	3.57	1.06	20	3.26	0.52	25	3.54	0.77	27	n.s.	-	-	-
Muscle
CK	U/l	174.02	74.57	19	200.53	208.21	25	167.36	119.89	27	n.s.	-	-	-
LDH	U/l	402.31	146.41	19	266.37	92.61	25	260.89	79.26	27	*	***	***	n.s.
Calcium	mmol/l	2.41	0.11	19	2.43	0.14	25	2.47	0.14	27	n.s.	-	-	-
Magnesium	mmol/l	0.74	0.07	19	0.72	0.09	25	0.78	0.08	27	n.s.	-	-	-
Triglycerides	mmol/l	0.65	1.18	19	0.63	0.38	25	1.03	0.49	27	***	*	***	**

Mean values, SD, and number of samples N are given separately for time periods before implantation and start of laboratory procedures (baseline, group 1), during the first three years after implantation and start of laboratory procedures (group 2), and later times (group 3). Column KW provides results of Kruskal–Wallis tests; p values were adjusted to conform to a FDR of 10%. Column paired tests indicates results of post hoc tests when Kruskal–Wallis tests rejected the null hypothesis of equal means. n.s., not significant; *p < 0.05, **p < 0.01, ***p < 0.001. U/l, units/l; G/L, 10⁹ U/l; T/l, 10¹² U/l.