Table 1

List of differentially expressed protein-coding gene transcripts between E15.5 sham and IUGR hippocampi

Gene pathways	Gene names	Fold changes
Wnt and PCP signaling	Wnt2b	↓3.8×
	Wnt3a	↓6×
	Wnt8b	↓2.7×
	Wnt9a	↓2.8×
	Wnt10a	↓3.3×
	Dkk1	↓5×
	Wif1	↓3.6×
	Rspo1, 2, 3	↓3.3×, 5.2×, 2.3×
	Sp5	↓2.1×
Endocannabinoid neuronal synapse/CREB signaling/glutamate receptor signaling/ neuropathic pain signaling/synaptic LTP/synaptogenesis signaling	Grm1, 5, 8	↑2.1×, 2.6×, 2.3×
	Grin3a	↑2.2×
	Gng4	↑3.4×

Wnt and PCP signaling pathways predicted to have downregulated activity included Wnt ligands (Wnt2b, Wnt3a, Wnt8b, Wnt9a, Wnt10a), Wnt inhibitors (Dkk1 and Wif1), activators for Wnt and PCP pathways (Rspo1, 2, 3), and readout of Wnt pathway (Sp5). Corresponding fold changes in gene expression are shown. Glutamate receptor signaling plus other signaling pathways predicted to have upregulated activity included the metabotropic glutamate receptors (Grm1, 5, 8), glutamate ionotropic receptor NMDA type subunit 3a (Grin3a), and G-protein subunit γ 4 (Gng4).