Table 2

Differentially expressed genes following PR-specific Otx2 invalidation.

2 days after 4 days after cKO8 days after cKO
Gene symbolLog2
FC
Adjusted
p-value
Gene
symbol
Log2
FC
Adjusted
p-value
Gene
symbol
Log2
FC
Adjusted
p-value
Upregulated genes
 Vmn1r151.0854.223E-12A330074K22Rik0.6915.520E-05A330074K22Rik0.9402.771E-08
 Frat20.7217.028E-05Pcdh90.5135.035E-04Cyp2j90.9782.905E-05
 1700030C10Rik0.5653.480E-03Pcdh11x0.6451.163E-035930430L01Rik0.7417.131E-05
 Dusp10.7876.451E-03Cdh120.6191.738E-03Ctif0.5627.917E-05
 Nr4a10.5061.435E-02L1cam0.5311.987E-03Tln20.5751.435E-04
Map1a0.5902.335E-03Cdkl50.4977.743E-04
Kndc10.5892.335E-03Adcy10.5202.169E-03
Tusc50.6072.944E-03Hydin0.7833.502E-03
Cdk140.5004.562E-03Fggy0.7361.005E-02
Grin2a0.5525.688E-03Faah0.5801.274E-02
Caln10.5157.558E-03Wsb2-ps0.7611.275E-02
Kif5a0.5197.810E-03Spta10.5051.358E-02
Mctp10.5607.987E-03Mettl40.5372.185E-02
Cdkl10.5688.289E-03Kif5a0.5142.424E-02
Rbfox10.5188.492E-03Map1b0.4972.424E-02
Sik10.5909.211E-03Map1a0.5292.696E-02
Lancl30.6791.040E-02Odc10.6272.747E-02
Hydin0.6561.077E-02Lancl30.6792.895E-02
Srgap10.5671.214E-02Pcdh11x0.5452.939E-02
Tmem151b0.5441.214E-02Gm470210.5703.193E-02
Gpr1580.5051.214E-02Cdh120.5223.693E-02
Pgr0.5981.415E-02Impg10.5023.766E-02
Hecw20.5121.446E-02Gm58980.5294.073E-02
Ar0.6251.560E-02Gm219550.7234.788E-02
Stc10.5271.652E-02Slc9a70.6154.897E-02
Kcnq30.5381.909E-02Srgap10.5454.993E-02
Atp2b30.5532.078E-02
Tfap2d0.5472.141E-02
Htr5a0.4972.677E-02
Pcdha60.6562.687E-02
Prlr0.5352.737E-02
D130079A08Rik0.5672.993E-02
Onecut30.5413.183E-02
Ppp1r1c0.5903.270E-02
Gm89830.6573.520E-02
Srl0.5403.528E-02
Pou4f10.5013.590E-02
Ndst40.4984.604E-02
Pcdha120.5504.654E-02
Klf120.5184.835E-02
Alk0.5024.851E-02
Downregulated genes
 Myh11-1.2784.007E-11Sod3-1.7445.984E-14Myh11-1.3174.348E-10
 Tagln-1.1512.092E-06Vcan-1.7115.984E-14Tgm1-1.2705.883E-08
 Tgm1-1.0681.058E-05Angptl2-1.7321.419E-13Gsta3-1.3242.696E-07
 Mlana-0.9801.372E-05Penk-1.6756.155E-13Tagln-1.2442.696E-07
 Gpnmb-1.0201.588E-05Cldn19-1.6401.474E-12Myl9-1.2124.121E-06
 Angptl2-1.1613.191E-05Ltbp1-1.5071.474E-12Rps3a1-0.8578.459E-06
 Myl9-1.1573.191E-05Myh11-1.3664.976E-12Mlana-1.0281.104E-05
 Wnt16-0.9023.191E-05Dio3-1.5496.758E-11Gpnmb-1.0352.905E-05
 Pmel-0.8993.191E-05Gsta3-1.5298.333E-11Ubc-0.8862.905E-05
 Matn3-0.6433.191E-05Mrc2-1.4951.400E-10Pmel-0.9304.049E-05
 Emilin2-1.0565.366E-05Col18a1-1.4291.400E-10Matn3-0.6824.339E-05
 4930435M08Rik-0.7305.366E-05Tgm1-1.3751.661E-10Emilin2-1.0796.306E-05
 Gsta3-1.1186.722E-05Serpine1-1.4521.398E-09Wnt16-0.8812.147E-04
 Rps3a1-0.7366.722E-05Ism2-1.4231.948E-094930435M08Rik-0.7332.147E-04
 Bfsp2-0.5131.099E-03Efemp1-0.8401.948E-09Bfsp2-0.5763.206E-04
 C2-0.9941.115E-03Bace2-1.4332.706E-09Purg-0.5014.664E-04
 Pld5-0.9481.405E-03Tagln-1.3253.211E-09Angptl2-1.0185.342E-04
 Thbd-0.9791.908E-03Matn2-1.3729.502E-09Edn3-0.9655.886E-04
 Npsr1-0.9741.935E-03Myl9-1.3371.715E-08Thbd-1.0026.007E-04
 Tyrp1-0.8212.090E-03Emp3-1.3691.769E-08C2-1.0056.464E-04
 Slc20a2-0.5692.809E-03Edn3-1.2991.875E-08Pld5-0.9197.127E-04
 Tyr-0.8383.912E-03Mlana-1.1622.164E-08Acta2-0.7967.173E-04
 Slc38a8-0.9214.018E-03Atp1a2-0.9653.882E-08Hpse-0.8881.152E-03
 Bace2-0.9067.009E-03Mgst1-1.3196.368E-08Fam20a-0.9261.183E-03
 Tspan10-0.7907.009E-03Rarres2-1.3156.372E-08Gm14268-0.7191.196E-03
 Mlph-0.7538.764E-03Slc38a8-1.3097.799E-08Slc38a8-0.9621.365E-03
 Ccdc3-0.7848.890E-03Rhoj-1.1777.799E-08Bace2-0.9492.010E-03
 Dcn-0.5801.780E-02Wnt16-1.0817.799E-08Tyrp1-0.8382.109E-03
 Lyz2-0.8091.841E-02Gpnmb-1.1631.081E-074930458D05Rik-0.9282.169E-03
 4932438H23Rik-0.7431.866E-02Bgn-1.2481.155E-07Shmt1-0.8672.169E-03
 Acta2-0.6362.156E-02Pmel-1.0541.384E-07Slc43a1-0.8212.169E-03
 Crybg1-0.7952.401E-02Col9a2-1.0811.399E-07Zfp566-0.6052.169E-03
 Smtn-0.8002.734E-02Fam129a-1.2921.437E-07Smtn-0.8632.228E-03
 Slc11a1-0.8113.130E-02Crhbp-1.2891.474E-07Adh1-0.8803.502E-03
 Ucp2-0.7873.486E-02Pld5-1.1801.894E-07Ociad2-0.7623.928E-03
 Papss2-0.6853.486E-02Npsr1-1.2772.014E-07AI464131-0.7223.970E-03
 Palmd-0.6174.928E-02Iqgap2-1.1552.153E-07Npsr1-0.8786.593E-03
 C130021I20Rik-0.5524.981E-02Bmp2-1.2394.286E-07Serpine1-0.8736.828E-03
Wfdc1-1.1435.264E-07Ctsk-0.7737.260E-03
Emilin2-1.1905.997E-07Papss2-0.6787.868E-03
Col1a2-1.1796.514E-07Gm44678-0.8578.088E-03
Tmprss11e-1.2226.979E-07Hbb-bs-0.8128.117E-03
Rps3a1-0.8676.979E-07Mlph-0.7548.948E-03
Wif1-1.0647.023E-07Gm38021-0.8558.998E-03
Zic4-1.2069.790E-07Tyr-0.7919.424E-03
Acta2-0.9611.378E-06Mmp14-0.5639.430E-03
Zic1-1.0271.426E-06Ucp2-0.7801.045E-02
Mdk-1.1131.515E-06Wdr95-0.7741.045E-02
Notum-1.1891.515E-06Gm26917-0.6361.045E-02
Klhdc7a-1.1851.515E-06Stac-0.8221.116E-02
Dsg2-1.1721.999E-06Cmtm3-0.7411.275E-02
Gpx3-1.1482.441E-06Wif1-0.7211.275E-02
Matn3-0.7062.799E-06Gxylt2-0.6371.275E-02
Mecom-1.1592.908E-06E230020A03Rik-0.5991.275E-02
F5-1.1273.302E-06Cnn1-0.5081.556E-02
Clec18a-1.0303.797E-06Dcn-0.5861.577E-02
Tyrp1-1.0274.437E-06Mdk-0.7491.623E-02
Rab38-1.1346.774E-06Dmgdh-0.5311.767E-02
Defb9-0.9801.042E-05Lrrc66-0.7911.808E-02
Mlph-0.9861.224E-05C130021I20Rik-0.5901.808E-02
Thbs2-1.1151.283E-05Gm28229-0.5831.872E-02
Stac-1.0981.347E-05Dpp4-0.7912.159E-02
Ociad2-0.9381.347E-05Slc24a5-0.7162.159E-02
Ifi30-0.8861.368E-05Gjb6-0.6092.250E-02
Papss2-0.8741.374E-05Palmd-0.5592.250E-02
Gldc-0.7221.374E-05Tspan10-0.7112.279E-02
Idh2-0.7701.785E-05Hbb-bt-0.7802.358E-02
Lox-1.0832.474E-05Pdgfc-0.5062.435E-02
Cldn1-1.0552.533E-05Nbl1-0.5402.465E-02
Bfsp2-0.5963.016E-05Nradd-0.6392.495E-02
Ddr2-1.0293.228E-05Gsx2-0.6432.747E-02
Gfpt2-1.0123.228E-05Uap1l1-0.6093.237E-02
Smtn-0.9963.228E-05Bgn-0.7213.273E-02
C2-1.0763.230E-05Eva1c-0.7383.356E-02
Fbn1-1.0703.322E-05Slc16a10-0.5893.356E-02
Ucp2-0.9893.838E-05Atp1a2-0.5383.397E-02
Lyz2-0.9733.878E-05Lox-0.7473.414E-02
Thbd-1.0534.596E-05Nkd2-0.7323.693E-02
Ackr4-1.0544.779E-05D130019J16Rik-0.7323.989E-02
Cnn2-1.0464.779E-05Selenop-0.5434.073E-02
Fgfr1-0.6424.841E-05Rny1-0.5564.975E-02
Dse-0.9265.106E-05
D630039A03Rik-1.0535.266E-05
Nid2-1.0515.679E-05
Nkd2-1.0336.397E-05
Mrc1-1.0246.814E-05
C4b-0.9737.233E-05
Fbln7-1.0207.709E-05
Slc4a5-0.7227.939E-05
Pkdcc-0.6237.975E-05
Colec12-1.0257.996E-05
Aebp1-0.9788.145E-05
Tnfrsf21-0.5468.368E-05
Col9a1-0.8868.502E-05
Tyr-0.9558.525E-05
Zic2-0.9908.529E-05
Galnt12-0.9839.635E-05
Otx1-0.9671.012E-04
Sned1-1.0161.152E-04
Rapsn-1.0161.156E-04
Trip6-0.6761.282E-04
Mrgprf-0.9631.392E-04
Dio3os-0.9951.447E-04
Plin4-0.9801.541E-04
Igfbp4-0.5611.541E-04
Serping1-0.9681.576E-04
Gja1-0.9081.620E-04
Ces1d-0.9361.670E-04
Slc13a4-0.9291.715E-04
Dsg1a-0.8501.776E-04
BC067074-0.9921.884E-04
Fbln2-0.9851.913E-04
Crtap-0.8782.026E-04
Prelp-0.6042.104E-04
Tfeb-0.5812.148E-04
Cdk2-0.8192.214E-04
Suclg2-0.9332.246E-04
Col9a3-0.7792.465E-04
Ctsc-0.6122.465E-04
Adh1-0.9402.482E-04
Rcn3-0.8792.932E-04
Tspan10-0.8802.993E-04
Mdfic-0.9313.412E-04
Gm14268-0.7054.307E-04
H2-Aa-0.9474.931E-04
Ptgds-0.9325.035E-04
Bambi-0.7175.035E-04
Fam107a-0.8645.145E-04
Tst-0.9365.613E-04
Boc-0.7486.106E-04
4930458D05Rik-0.9216.644E-04
Slc26a4-0.8436.644E-04
Aldh1a3-0.9157.082E-04
2310034O05Rik-0.8917.269E-04
Timp3-0.7207.310E-04
Id3-0.8108.239E-04
Slc4a11-0.9128.411E-04
Perp-0.9138.428E-04
Ephx1-0.8458.534E-04
Fbn2-0.8991.040E-03
Zfp185-0.8551.065E-03
Slc24a5-0.8171.163E-03
Optc-0.8021.219E-03
F11r-0.7831.274E-03
Frrs1-0.8411.346E-03
Tgfbr3-0.7771.435E-03
Fbln1-0.7841.436E-03
Nbl1-0.6201.474E-03
Fkbp9-0.7661.621E-03
Veph1-0.8841.662E-03
Bmp4-0.8781.670E-03
1810022K09Rik-0.5021.670E-03
4930523C07Rik-0.8791.738E-03
Crocc2-0.8601.777E-03
Adamts9-0.7271.780E-03
Cald1-0.5491.798E-03
Selenop-0.6471.887E-03
Cd74-0.8501.906E-03
Olfml2a-0.8401.953E-03
Cyba-0.7151.953E-03
P3h1-0.7431.981E-03
Chmp4c-0.8692.023E-03
Clec14a-0.8482.158E-03
Tmem176a-0.6582.164E-03
P2rx6-0.8562.172E-03
Fmod-0.8052.172E-03
Slc16a12-0.7752.188E-03
Dcn-0.6222.188E-03
Piezo1-0.8342.313E-03
Gm7694-0.6842.313E-03
Tbx22-0.7622.335E-03
Gm44250-0.8572.391E-03
Flna-0.6472.391E-03
Gm26917-0.6442.567E-03
Ltbp2-0.7802.675E-03
Rapgef3-0.6272.798E-03
Nfatc4-0.7583.117E-03
Cmtm3-0.7533.245E-03
Arhgef5-0.7913.692E-03
Loxl3-0.6394.023E-03
Lamb2-0.5534.325E-03
Pon2-0.6354.345E-03
Rdm1-0.6464.497E-03
Cpz-0.7424.565E-03
Gypc-0.8184.607E-03
Nxn-0.6664.657E-03
Cyp4f15-0.8184.689E-03
H2-Eb1-0.8184.772E-03
Best2-0.6314.996E-03
Tlcd1-0.5815.262E-03
Blnk-0.8115.298E-03
Ccnd2-0.7935.298E-03
Ifitm2-0.7995.319E-03
Gas1-0.5085.477E-03
Eps8l2-0.7715.511E-03
Ctsh-0.6295.590E-03
Rhbdf1-0.6785.612E-03
Renbp-0.5835.768E-03
Eya1-0.6995.780E-03
Pon3-0.8036.065E-03
Ces5a-0.6826.065E-03
Ecm1-0.6516.164E-03
Pdgfrl-0.7366.211E-03
Efemp2-0.5266.239E-03
Ackr3-0.7626.363E-03
Acads-0.5606.473E-03
Cd82-0.6466.646E-03
Ankrd44-0.6016.646E-03
Tcim-0.6626.706E-03
Gpc4-0.7076.752E-03
Mfap4-0.6496.782E-03
C1s1-0.7877.613E-03
Lrig3-0.6117.810E-03
Agpat2-0.7557.846E-03
Tmem176b-0.5988.193E-03
Slc6a13-0.7288.241E-03
Fbln5-0.7818.253E-03
Apoe-0.5188.275E-03
Bdh2-0.7118.317E-03
AI464131-0.6228.474E-03
Cgnl1-0.6148.474E-03
Gm45407-0.7758.880E-03
Nectin3-0.5618.883E-03
Ehd2-0.6088.986E-03
Slc25a34-0.7459.339E-03
Dpp4-0.7719.344E-03
Ggt5-0.7699.344E-03
Pcolce-0.7569.344E-03
Gprc5c-0.7479.344E-03
Osgin1-0.7459.344E-03
Atp10d-0.6729.344E-03
Cobll1-0.6689.344E-03
Thap6-0.5759.826E-03
Gm38021-0.7679.845E-03
Slc45a2-0.7511.026E-02
1700055D18Rik-0.7081.065E-02
Slc11a1-0.7581.068E-02
Pear1-0.7361.073E-02
Htra1-0.6161.080E-02
Josd2-0.5341.083E-02
Shmt1-0.6971.098E-02
4930594M22Rik-0.7581.100E-02
Ahnak-0.7211.105E-02
Plekhg3-0.5161.105E-02
Slc22a8-0.7341.122E-02
Gm43637-0.7231.122E-02
Fcgrt-0.7141.122E-02
Dct-0.6331.214E-02
Nedd9-0.5441.214E-02
Stx11-0.6441.219E-02
Ctsk-0.6631.238E-02
Abcc6-0.6051.255E-02
Pdlim4-0.6731.273E-02
Fzd8-0.5451.342E-02
Tmem132b-0.5111.342E-02
Tmc6-0.7341.352E-02
Ptgr1-0.7181.363E-02
Cavin2-0.7331.372E-02
Syngr2-0.6671.372E-02
Gli2-0.6851.374E-02
Ager-0.7091.399E-02
Dok1-0.7361.419E-02
Pqlc3-0.7351.419E-02
Stab1-0.7081.419E-02
Plekhg2-0.5991.419E-02
AC152827.1-0.6401.447E-02
Echdc2-0.5741.460E-02
Tmem63a-0.6271.535E-02
Cd63-0.5501.619E-02
Ppfibp2-0.6831.626E-02
Vangl1-0.6031.651E-02
Slc2a1-0.5041.651E-02
Pgf-0.7241.652E-02
Kdelr3-0.7011.704E-02
Vstm4-0.5411.740E-02
A730049H05Rik-0.7201.751E-02
Hpse-0.6521.778E-02
Zic5-0.6981.785E-02
Wdr86-0.6811.785E-02
Sema3b-0.6111.785E-02
Pde3b-0.5161.785E-02
Sult1a1-0.7141.796E-02
Slc6a12-0.6261.892E-02
Itpripl2-0.7121.919E-02
Cldn2-0.5801.929E-02
Sqor-0.7091.957E-02
Iyd-0.6971.991E-02
Uap1l1-0.5702.070E-02
Mfrp-0.6692.118E-02
Abcc4-0.6552.118E-02
Gm42716-0.6802.132E-02
Nek8-0.5432.132E-02
Crybg1-0.6372.169E-02
C1qtnf6-0.7032.172E-02
Il17rc-0.6672.190E-02
Nradd-0.5772.303E-02
Mxra8-0.6822.333E-02
Tmem140-0.6972.336E-02
Stk26-0.6782.336E-02
1500015O10Rik-0.5932.336E-02
Aldh1a7-0.6842.360E-02
Antxr1-0.6112.368E-02
Vill-0.6942.394E-02
Megf6-0.6932.394E-02
Tspo-0.6542.471E-02
Slc35f3-0.6892.475E-02
Scube1-0.6752.481E-02
1600023N17Rik-0.6422.481E-02
Abi3bp-0.6842.495E-02
Ttc16-0.6672.519E-02
Fmo1-0.6402.519E-02
Gpr137b-0.5252.519E-02
Ano1-0.6062.708E-02
D630024D03Rik-0.6582.737E-02
Igfbp5-0.5632.741E-02
Gm42555-0.6832.747E-02
Trim63-0.6692.749E-02
Wtip-0.5372.848E-02
Fam20a-0.6412.956E-02
Ptpn14-0.6042.976E-02
Gli3-0.5372.976E-02
Stard8-0.5703.068E-02
Hes1-0.5043.086E-02
Folr1-0.6343.092E-02
Itpr3-0.6523.139E-02
Dll1-0.5263.183E-02
Tns1-0.5443.250E-02
Tnfrsf19-0.5863.266E-02
Gm30698-0.6463.269E-02
Mfap2-0.6293.269E-02
Hhip-0.6633.270E-02
Smco4-0.6553.270E-02
Fkbp10-0.6193.278E-02
Gm44037-0.6173.350E-02
1700124L16Rik-0.5763.404E-02
P4ha2-0.5603.410E-02
Rab32-0.6543.447E-02
Cavin1-0.6423.447E-02
Lrrk1-0.6573.479E-02
2610035F20Rik-0.6553.543E-02
Lama5-0.6113.543E-02
Pla2g4a-0.6543.590E-02
Gm25835-0.6513.590E-02
Aqp5-0.6553.618E-02
Ephb4-0.6143.625E-02
Shc1-0.5073.671E-02
Gsn-0.6063.685E-02
Timp1-0.6503.735E-02
Clec3b-0.6433.842E-02
Cldn7-0.6303.927E-02
2810030D12Rik-0.5083.927E-02
Lgals1-0.5973.940E-02
Igf2bp1-0.5614.000E-02
Ntf3-0.5944.039E-02
Ogn-0.4974.044E-02
Gm44678-0.6404.062E-02
Slc35g1-0.6084.064E-02
Ahcy-0.6344.097E-02
Slc39a12-0.6224.167E-02
Serpinh1-0.6424.169E-02
Rbm47-0.6364.205E-02
Maob-0.5824.210E-02
Tead2-0.5614.272E-02
Ptpn15-0.6104.275E-02
Slc4a4-0.5284.503E-02
Gje1-0.5104.511E-02
Rassf9-0.6334.516E-02
Six5-0.5794.559E-02
Gm20383-0.6064.573E-02
Plekhf1-0.6214.617E-02
Mboat1-0.6034.637E-02
Ch25h-0.5384.744E-02
Tmem150a-0.5144.753E-02
Snora73b-0.6284.835E-02
Wls-0.5804.841E-02
Adamts2-0.5774.841E-02
Loxl1-0.6104.858E-02
Gm12689-0.6204.936E-02