Table 4

Statistical parameters from three-way mixed model ANOVA assessing the effect of age and PNA treatment on the KNDy cell response to senktide (Fig. 3)

Effect	Statistic	Generalized η²
Senktide	F_(1,38) = 52.35, p < 0.0001	0.395
Age	F_(1,38) = 0.7515, p = 0.391	0.010
PNA treatment	F_(1,38) = 2.235, p = 0.143	0.030
Senktide × age	F_(1,38) = 0.5459, p = 0.465	0.007
Senktide × PNA treatment	F_(1,38) = 2.051, p = 0.160	0.025
Age × treatment	F_(1,38) = 0.2633, p = 0.611	0.004
Senktide × age × PNA treatment	F_(1,38) = 1.179, p = 0.284	0.015
Bonferroni’s multiple comparisons test	Mean diff (Hz), 95% CI of diff	Statistic
SK 3wk-CON – C 3wk-CON	Diff 2.36, [CI 0.59, 4.13]	t₍₃₈₎ = 4.055, p = 0.003
SK 3wk-PNA – C 3wk-PNA	Diff 1.04, [CI −0.41, 2.49]	t₍₃₈₎ = 2.192, p = 0.415
SK adult-CON – C adult-CON	Diff 2.178, [CI 0.40, 3.95]	t₍₃₈₎ = 3.743, p = 0.007
SK adult-PNA – C adult-PNA	Diff 2.00, [CI 0.66, 3.34]	t₍₃₈₎ = 4.540, p = 0.001
C 3wk-PNA – C 3wk-CON	Diff 0.11, [CI −1.51, 1.72]	t₍₇₆₎ = 0.194, p > 0.999
C adult-PNA – C adult-CON	Diff −0.18, [CI −1.75, 1.39]	t₍₇₆₎ = 0.340, p > 0.999
SK 3wk-PNA – SK 3wk-CON	Diff −1.21, [CI −2.82, 0.40]	t₍₇₆₎ = 2.223, p = 0.350
SK adult-PNA – SK adult-CON	Diff −0.36, [CI −1.93, 1.20]	t₍₇₆₎ = 0.682, p > 0.999
C adult-CON – C 3wk-CON	Diff 0.19, [CI −1.58, 1.95]	t₍₇₆₎ = 0.315, p > 0.999
C adult-PNA – C 3wk-PNA	Diff −0.10, [CI −1.49, 1.29]	t₍₇₆₎ = 0.207, p > 0.999
SK adult-CON – SK 3wk-CON	Diff 0.01, [CI −1.76, 1.77]	t₍₇₆₎ = 0.011, p > 0.999
SK adult-PNA – SK 3wk-PNA	Diff 0.86, [CI −0.53, 2.25]	t₍₇₆₎ = 1.825, p = 0.863

The effect size, generalized η², is reported for each effect. Bonferroni multiple comparisons for cells that differ by only one factor. Bold indicates p < 0.05.